Pubblicazioni

Autori:

Maines, Evelina; Tadiotto, Elisa; Morandi, Grazia; Fedrizzi, Michela; Gaudino, Rossella; Cavarzere, Paolo; Guzzo, Alessandra; Antoniazzi, Franco

Titolo:

Hypocalcemia following Neridronate Administration in Pediatric Patients with Osteogenesis Imperfecta: A Prospective Observational Study

Anno:

2020

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

JOURNAL OF PEDIATRIC GENETICS

ISSN Rivista:

2146-4596

N° Volume:

9

Numero o Fascicolo:

2

Intervallo pagine:

93-100

Parole chiave:

children; hypocalcemia; neridronate; osteogenesis imperfecta; vitamin D deficiency

Breve descrizione dei contenuti:

The use of intravenous bisphosphonates has been linked to hypocalcemia both in children and adults with osteogenesis imperfecta (OI). The aims of this study were: (1) to investigate the incidence of hypocalcemia in the first 48 hours (T48) after neridronate infusion in a pediatric population with OI and (2) to assess any correlation between the baseline values of calcium, vitamin D (25-hydroxyvitamin D) and bone turnover markers, and the postinfusion calcium values. We conducted a prospective observational study on 37 pediatric patients. All patients were treated with a single infusion of neridronate at a dose of 1 to 2 mg/kg. The study provided two postinfusion reassessments: 24 hours (T24) and T48 after neridronate administration. Hypocalcemia was observed in 11% of patients at T24 and in 50% of patients at T48 from neridronate infusion. We observed a positive linear correlation between the baseline vitamin D values and postinfusion calcium values, both at baseline and at T24 and T48. Hypocalcemia was mild and asymptomatic in all cases. Postinfusion calcium levels were related to baseline vitamin D levels. Consequently, low vitamin D levels should be considered a significant risk factor for hypocalcemia and should be carefully investigated and treated before neridronate infusion.

Id prodotto:

117931

Handle IRIS:

11562/1030771

ultima modifica:

15 novembre 2022

Citazione bibliografica:

Maines, Evelina; Tadiotto, Elisa; Morandi, Grazia; Fedrizzi, Michela; Gaudino, Rossella; Cavarzere, Paolo; Guzzo, Alessandra; Antoniazzi, Franco, Hypocalcemia following Neridronate Administration in Pediatric Patients with Osteogenesis Imperfecta: A Prospective Observational Study «JOURNAL OF PEDIATRIC GENETICS» , vol. 9 , n. 2 , 2020 , pp. 93-100

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo