Pubblicazioni

Autori:

Romano, Francesco; Cozzi, Mariano; Casati, Stefano; Bosello, Francesca; Zaffalon, Chiara; Trinco, Andrea; Pellegrini, Marco; Invernizzi, Alessandro; Staurenghi, Giovanni; Salvetti, Anna Paola

Titolo:

Unveiling the Hidden: Early Manifestations of Extensive Macular Atrophy with Pseudodrusen-like appearance

Anno:

2023

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

RETINAL CASES & BRIEF REPORTS

ISSN Rivista:

1935-1089

N° Volume:

First published online: 01 November 2023

Intervallo pagine:

N/A-N/A

Parole chiave:

EMAP, extensive macular atrophy with pseudodrusen-like appearance, multimodal imaging, microperimetry, early manifestations, high-magnification module, rod dysfunction, Hi-Res OCT

Breve descrizione dei contenuti:

Purpose: To describe novel microperimetry and imaging findings in two patients affected by extensive macular atrophy with pseudodrusen-like appearance (EMAP) without signs of retinal pigment epithelium (RPE) atrophy. Methods: Case series. Both patients underwent mesopic and dark-adapted two-color scotopic microperimetry, followed by multimodal imaging assessment including ultra-widefield photography, fundus autofluorescence (AF), high-resolution optical coherence tomography (Hi-Res OCT), OCT angiography and high-magnification module (HMM). Results: Albeit normal visual acuity, both patients had a significant reduction of retinal sensitivity - especially under scotopic cyan conditions. One patient had macular pigment abnormalities, while the combination of blue and near-infrared AF modalities highlighted different patterns of pseudodrusen-like lesions.Of notice, Hi-Res OCT revealed a marked separation between the RPE and Bruch's membrane, containing a hyperreflective material with two different reflectivities. OCT angiography excluded the presence of macular neovascularization and documented several choriocapillaris flow voids. HMM images showed severe alteration of photoreceptors' mosaic in the perifovea. Conclusions: Our comprehensive assessment of two stage 1 EMAP patients revealed a predominant damage of perifoveal rods over areas of RPE-Bruch's membrane separation. These findings underscore the importance of basal laminar deposits in the initial stages of EMAP, contributing to a deeper understanding of its underlying mechanisms.

Id prodotto:

141750

Handle IRIS:

11562/1142526

ultima modifica:

14 ottobre 2024

Citazione bibliografica:

Romano, Francesco; Cozzi, Mariano; Casati, Stefano; Bosello, Francesca; Zaffalon, Chiara; Trinco, Andrea; Pellegrini, Marco; Invernizzi, Alessandro; Staurenghi, Giovanni; Salvetti, Anna Paola, Unveiling the Hidden: Early Manifestations of Extensive Macular Atrophy with Pseudodrusen-like appearance «RETINAL CASES & BRIEF REPORTS» , vol. First published online: 01 November 2023 , 2023 , pp. N/A-N/A

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo