Pubblicazioni

Autori:

Franceschi, Roberto; Mozzillo, Enza; Di Candia, Francesca; Rosanio, Francesco Maria; Leonardi, Letizia; Liguori, Alice; Micheli, Francesca; Cauvin, Vittoria; Franzese, Adriana; Piona, Claudia; Marcovecchio, M Loredana

Titolo:

A systematic review of the prevalence, risk factors and screening tools for autonomic and diabetic peripheral neuropathy in children, adolescents and young adults with type 1 diabetes

Anno:

2022

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

Acta Diabetologica

ISSN Rivista:

0940-5429

N° Volume:

59

Numero o Fascicolo:

3

Intervallo pagine:

293-308

Parole chiave:

Cardiac autonomic neuropathy; Diabetic peripheral neuropathy; Risk factors; Screening tools; Youths

Breve descrizione dei contenuti:

Aims We aimed to estimate the prevalence of Diabetic peripheral neuropathy (DPN) and Cardiac autonomic neuropathy (CAN) in youth with type 1 diabetes; identify key risk factors; identify the most useful tests for the diagnostic evaluation of DPN and CAN; identify key treatment options for DPN and CAN. Methods A systematic search was performed including studies published in the last 15 years. PICO framework was used in the selection process and evidence was assessed using the GRADE system. Results A total of 758 studies were identified and a final number of 49 studies were included in this systematic review. According to moderate-high level quality studies, the prevalence of probable DPN, ranged between 13.5 and 62%; subclinical DPN between 22 and 88%; confirmed DPN between 2.6 and 11%. The Michigan Neuropathy Screening Instrument was the tool with higher sensitivity and specificity for detecting DPN, which needs to be confirmed by nerve conduction velocity. The prevalence of CAN was 4-39%. Specific treatment options for DPN or CAN in patients younger than 25 years are not available. Key risk factors for DPN and CAN are hyperglycemia/HbA1c, age, diabetes duration, the presence of other microvascular complications, waist/height ratio, lipid profile and blood pressure. For CAN, additional risk factors were cigarette smoking, BMI and total daily insulin. Conclusions Prevalence of neuropathy in youth with type 1 diabetes varies depending on different screening methods and characteristics of the study populations. However, the assessed studies confirmed a relatively high prevalence of subclinical neuropathy, reiterating the importance of early identification of risk factors to prevent this complication.

Id prodotto:

142069

Handle IRIS:

11562/1144139

ultima modifica:

28 ottobre 2024

Citazione bibliografica:

Franceschi, Roberto; Mozzillo, Enza; Di Candia, Francesca; Rosanio, Francesco Maria; Leonardi, Letizia; Liguori, Alice; Micheli, Francesca; Cauvin, Vittoria; Franzese, Adriana; Piona, Claudia; Marcovecchio, M Loredana, A systematic review of the prevalence, risk factors and screening tools for autonomic and diabetic peripheral neuropathy in children, adolescents and young adults with type 1 diabetes «Acta Diabetologica» , vol. 59 , n. 3 , 2022 , pp. 293-308

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