Pubblicazioni

Autori:

Tedesco, Erika; Ceccato, Sofia; Torazzi, Alessandro; Santin, Laura; Losso, Lorenzo; Bottardi, Andrea; Casari, Rebecca; Melchiori, Silvia; Secchettin, Erica; Ferrero, Valeria; Arzenton, Elena; Marini, Paola; Lugoboni, Fabio; Chiamulera, Cristiano

Titolo:

Cytisine for smoking cessation in hospitalised smokers with cardiovascular diseases: an observational study

Anno:

2025

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

INTERNAL AND EMERGENCY MEDICINE

ISSN Rivista:

1828-0447

N° Volume:

20

Numero o Fascicolo:

3

Intervallo pagine:

817-828

Parole chiave:

Addiction; Cardiovascular disease; Cytisine; Hospital; Safety; Smoking cessation

Breve descrizione dei contenuti:

Cigarette smoke is a significant risk factor for cardiovascular diseases (CVD). Among pharmacotherapy for smoking cessation, the plant alkaloid cytisine (CYT) -a nicotinic receptors partial agonist- has been shown to have a safe profile, with a minimal risk for drug interactions. Since previous studies have excluded CVD patients, there are few existing data examining CYT safety in this critical population. An observational prospective study was conducted in the Verona University Hospital (AOUI), Italy, to assess the safety and efficacy of CYT for smoking cessation. Thirty-six hospitalised participants from the Cardiology Department received oral CYT 1.5 mg for 25 days, according to the West Dosing Schedule (6 capsules for the first 3 days, gradually decreased up to 2 capsules on the last 6 days), in combination with supportive care. The primary endpoint was CYT safety, with 11 mild-moderate Adverse Drug Reactions (ADRs) reported by 9 (25%) participants. Initial insomnia (11%), nausea (6%), sleep disorders (6%), headache (3%), gastritis (3%), and diarrhoea (3%) were the most frequent symptoms. No serious or unexpected ADRs were identified, with no increase in cardiovascular events. Efficacy was assessed as self-reported 7-day point prevalence abstinence (PPA) at 3, 6 and 12 months post-quit. At the first follow-up, abstinence was also biochemically verified by exhaled carbon monoxide (CO) measurement, which was confirmed for 36% of participants. Considering lost to follow-up as relapsed patients, the PPA was 50%, 47% and 36% at 1st, 2nd and 3rd follow-up, respectively. These results may suggest that CYT has a well-established safety profile in hospitalised CVD patients, but further investigation is needed.

Note:

Epub 2025 Feb 12

Id prodotto:

147084

Handle IRIS:

11562/1168891

ultima modifica:

28 agosto 2025

Citazione bibliografica:

Tedesco, Erika; Ceccato, Sofia; Torazzi, Alessandro; Santin, Laura; Losso, Lorenzo; Bottardi, Andrea; Casari, Rebecca; Melchiori, Silvia; Secchettin, Erica; Ferrero, Valeria; Arzenton, Elena; Marini, Paola; Lugoboni, Fabio; Chiamulera, Cristiano, Cytisine for smoking cessation in hospitalised smokers with cardiovascular diseases: an observational study «INTERNAL AND EMERGENCY MEDICINE» , vol. 20 , n. 3 , 2025 , pp. 817-828

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo