Pubblicazioni

Bisphosphonate-associated osteonecrosis can hide jaw metastases  (2007)

Autori:
A. Bedogni; G. Saia; M. Ragazzo; G. Bettini; P. Capelli; E. D'Alessandro; PF. Nocini; L. Lo Russo; L. Lo Muzio ; S. Blandamura.
Titolo:
Bisphosphonate-associated osteonecrosis can hide jaw metastases
Anno:
2007
Tipologia prodotto:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Nazioni degli autori:
ITALIA
Lingua:
Inglese
Formato:
A Stampa
Referee:
Nome rivista:
Bone
ISSN Rivista:
8756-3282
Intervallo pagine:
942-945
Parole chiave:
Bisphosphonate, Osteonecrosis, Metastasis, Jawbone, Osteomyelitis
Breve descrizione dei contenuti:
Background: Osteonecrosis of the jaw is a well known potential complication of bisphosphonate treatment but its pathogenesis is poorly understood. The current management of patients with bisphosphonate-associated osteonecrosis (BON) is based on expert recommendations and there is a recognized need of better evidence. We report two cases where BON hid jaw metastases and use them to discuss some limitations of the current recommendations. Patients: Two patients undergoing long-term I.V. amino-bisphosphonate treatment for metastatic cancer presented with areas of intraorally exposed jawbone. Bisphosphonate-associated osteonecrosis was diagnosed on the basis of medical history, clinical and radiological features. They underwent surgical resection of the affected jaw due to unrelenting pain and lack of response to conservative treatments. Results: Histological examination of the surgical specimen revealed cancer cells at the margins of the site of osteonecrosis. Our patients did not undergo bone biopsy according to current recommendations, due to lack of clinical and radiological signs suggestive of jaw metastases. Conclusions: Our findings show that: i) patients with BON may also have jaw metastases; ii) there may not be clinical or imaging hints to this fact and; iii) that a biopsy based on careful selection of the site (with inclusion of necrotic margins) may be needed to reach the correct diagnosis. Further studies should be performed on this topic because of its very important prognostic implications.
Id prodotto:
45798
Handle IRIS:
11562/312999
depositato il:
24 ottobre 2007
ultima modifica:
2 novembre 2016
Citazione bibliografica:
A. Bedogni; G. Saia; M. Ragazzo; G. Bettini; P. Capelli; E. D'Alessandro; PF. Nocini; L. Lo Russo; L. Lo Muzio ; S. Blandamura., Bisphosphonate-associated osteonecrosis can hide jaw metastases «Bone»2007pp. 942-945

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