Publications

Authors:

Brunello, A.; Saia, G.; Bedogni, Alberto; Scaglione, D.; Basso, U.

Title:

Worsening of osteonecrosis of the jaw during treatment with sunitinib in a patient with metastatic renal cell carcinoma

Year:

2009

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

Sì

Name of journal:

Bone

ISSN of journal:

8756-3282

Page numbers:

173-175

Keyword:

osteonecrosis; jaw; sunitinib; cancer

Short description of contents:

We report on the potential association of suspected bisphosphonate-associated osteonecrosis of the jaw (BRONJ) recurrence with the use of the novel antiangiogenic drug sunitinib. A 59 year-old patient affected by metastatic renal cell carcinoma (RCC) and established BRONJ experienced consecutive episodes of painful jaw infection with cutaneous fistula and bone sequestration which occurred during active treatment with sunitinib, improved after discontinuation and antibiotic therapy, then rapidly worsened with resumption of sunitinib. We hypothesize that the potent antiangiogenic activity of sunitinib may amplify the inhibition of bone remodeling exerted by aminobisphosphonates entrapped within the osteonecrotic mineral matrix, antagonize mucosal healing and expose to infections during treatment. This supports the emerging role of soft-tissue damage in the pathogenesis of osteonecrosis of the jaw.

Product ID:

51455

Handle IRIS:

11562/334274

Deposited On:

March 29, 2012

Last Modified:

November 14, 2022

Bibliographic citation:

Brunello, A.; Saia, G.; Bedogni, Alberto; Scaglione, D.; Basso, U., Worsening of osteonecrosis of the jaw during treatment with sunitinib in a patient with metastatic renal cell carcinoma «Bone» , 2009 , pp. 173-175

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