Pubblicazioni

Long-term outcomes of surgical resection of the jaws in cancer patients with bisphosphonate-related osteonecrosis  (2011)

Autori:
Bedogni, A.; Saia, G.; Bettini, G.; Tronchet, A.; Totola, A.; Bedogni, G.; Ferronato, G.; Nocini, PF.; Blandamura, S.
Titolo:
Long-term outcomes of surgical resection of the jaws in cancer patients with bisphosphonate-related osteonecrosis
Anno:
2011
Tipologia prodotto:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Lingua:
Inglese
Referee:
No
Nome rivista:
ORAL ONCOLOGY
ISSN Rivista:
1368-8375
N° Volume:
47
Numero o Fascicolo:
5
Intervallo pagine:
420-424
Parole chiave:
surgical resection, cancer, bisphosphonate, osteonecrosis
Breve descrizione dei contenuti:
Surgical treatment of bisphosphonate-related osteonecrosis of the jaw (BRONJ) is controversial. Current recommendations contraindicate aggressive surgery because its results are unpredictable and may trigger disease progression. In this prospective study, we assessed the effectiveness of surgical resection of the jaws in cancer patients with BRONJ. Between June 2004 and July 2009, 30 cancer patients with refractory BRONJ underwent surgical resection of the jaws at our Units. They were followed-up weekly for the first month, at 3-month intervals up to 1 year, and at 6-month intervals up to 2 years. Panoramic radiographs and CT-scan were obtained at 3, 6, 12, 18 and 24 months. Primary outcomes were the 24-month recurrence rate of BRONJ and the 24-month mortality rate. Secondary outcomes were post-operative complications, duration of hospital stay after surgery, time to return to oral diet, and degree of oral pain.The 30 patients had a median age of 66 years and were mostly females (80%). Twenty-eight underwent a single resection and two had both jaws resected, for a total of 32 resected jaws. The cumulative recurrence rate of BRONJ in resected jaws 3.1% and 9.4% at 3 and 6 months, respectively. All the jaws with recurrent BRONJ had osteomyelitis at the margins of bone resection. The cumulative incidence of death was 3%, 12% and 16% at 12, 18 and 24 months.Surgical resection of BRONJ was highly effective, with few post-operative complications and were not associated with long-term mortality.
Id prodotto:
62107
Handle IRIS:
11562/363461
depositato il:
28 ottobre 2013
ultima modifica:
20 marzo 2018
Citazione bibliografica:
Bedogni, A.; Saia, G.; Bettini, G.; Tronchet, A.; Totola, A.; Bedogni, G.; Ferronato, G.; Nocini, PF.; Blandamura, S., Long-term outcomes of surgical resection of the jaws in cancer patients with bisphosphonate-related osteonecrosis «ORAL ONCOLOGY» , vol. 47 , n. 52011pp. 420-424

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo IRIS

Progetti Collegati
Titolo Dipartimento Responsabili
<<indietro

Attività

Strutture