Pubblicazioni

Autori:

Mauro, Margherita; Camoglio, Francesco Saverio; Piccoli, Pierluigi; De Bortoli, Massimiliano; Balter, Rita; Pegoraro, Anna; Cesaro, Simone

Titolo:

The Use of Splenectomy to Manage Platelet Transfusion Refractoriness due to Anti-Human Leukocyte Antibodies in Allogeneic Stem Cell Transplantation

Anno:

2016

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

PEDIATRIC REPORTS

ISSN Rivista:

2036-749X

N° Volume:

8

Numero o Fascicolo:

1

Intervallo pagine:

1-3

Parole chiave:

allogeneic stem cell transplantation; alloimmunized patients; anti-HLA; splenectomy; transfusion refractoriness

Breve descrizione dei contenuti:

In patients undergoing hematopoietic stem cell transplantation (HSCT), refractoriness to platelet transfusion has been associated with graft failure, delayed engraftment, early mortality and decreased overall survival. Therapeutic strategies include plasma exchange, immunoglobulins, rituximab, and splenectomy. We describe here three patients with refractoriness to platelet transfusion due to anti-human leukocyte antibodies who were splenectomized before HSCT (two cases) and after HSCT (one case) due to the lack of efficacy of other therapies. Splenectomy was uneventful. All three patients achieved a full donor engraftment. We suggest that splenectomy is feasible and effective in HSCT patients to reduce the risk of graft failure or delayed engraftment.

Id prodotto:

93802

Handle IRIS:

11562/944770

ultima modifica:

14 novembre 2022

Citazione bibliografica:

Mauro, Margherita; Camoglio, Francesco Saverio; Piccoli, Pierluigi; De Bortoli, Massimiliano; Balter, Rita; Pegoraro, Anna; Cesaro, Simone, The Use of Splenectomy to Manage Platelet Transfusion Refractoriness due to Anti-Human Leukocyte Antibodies in Allogeneic Stem Cell Transplantation «PEDIATRIC REPORTS» , vol. 8 , n. 1 , 2016 , pp. 1-3

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