Pubblicazioni

Autori:

Pio, Luca; Avanzini, Stefano; Mattioli, Girolamo; Martucciello, Giuseppe; Sementa, Angela Rita; Conte, Massimo; Gigliotti, Annarita; Granata, Claudio; Leva, Ernesto; Fagnani, Anna Maria; Caccioppoli, Umberto; Tedesco, Nino; Schleef, Jurgen; Tirtei, Elisa; Siracusa, Fortunato; D'Angelo, Paolo; Lelli Chiesa, Pierluigi; Miglionico, Lucia; Noccioli, Bruno; Severi, Elisa; Carlini, Claudio; Vaccarella, Francesco; Camoglio, Francesco Saverio; Cesaro, Simone; Narciso, Alessandra; Riccipetitoni, Giovanna; Cecchetto, Giovanni; Inserra, Alessandro

Titolo:

Perioperative management of hypertensive neuroblastoma: A study from the Italian Group of Pediatric Surgical Oncologists (GICOP)

Anno:

2017

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

Journal of Pediatric Surgery

ISSN Rivista:

0022-3468

N° Volume:

52

Numero o Fascicolo:

10

Intervallo pagine:

1633-1636

Parole chiave:

Hypertension; IDRFs; Neuroblastoma; Pediatric surgical oncology; Risk factors

Breve descrizione dei contenuti:

Background Hypertension (HT) is rarely reported in patients affected by Neuroblastoma (NB), and management guidelines are lacking. Clinical features and perioperative medical treatment in such patients were reviewed to 1) ascertain whether a shared treatment strategy exists among centers and 2) if possible, propose some recommendations for the perioperative management of HT in NB patients. Methods A retrospective multicenter survey was conducted on patients affected by NB who presented HT symptoms. Results From 2006 to 2014, 1126 children were registered in the Italian Registry of Neuroblastoma (RINB). Of these, 21 with HT (1.8%) were included in our analysis. Pre- and intraoperative HT management was somewhat dissimilar among the participating centers, apart from a certain consistency in the intraoperative use of the alpha-1 blocker urapidil. Six of the 21 patients (28%) needed persistent antihypertensive treatment at a median follow-up of 36 months (range 4–96 months) despite tumor removal. Involvement of the renal pedicle was the only risk factor constantly associated to HT persistency following surgery. A correlation between the presence of HT and the secretion of specific catecholamines and/or compression of the renal vascular pedicle could not be demonstrated. Conclusion Based on this retrospective review of NB patients with HT, no definite therapeutic protocol can be recommended owing to heterogeneity of adopted treatments in different centers. A proposal of perioperative HT management in NB patients is however presented. Level of evidence IV.

Id prodotto:

98639

Handle IRIS:

11562/967435

ultima modifica:

28 novembre 2022

Citazione bibliografica:

Pio, Luca; Avanzini, Stefano; Mattioli, Girolamo; Martucciello, Giuseppe; Sementa, Angela Rita; Conte, Massimo; Gigliotti, Annarita; Granata, Claudio; Leva, Ernesto; Fagnani, Anna Maria; Caccioppoli, Umberto; Tedesco, Nino; Schleef, Jurgen; Tirtei, Elisa; Siracusa, Fortunato; D'Angelo, Paolo; Lelli Chiesa, Pierluigi; Miglionico, Lucia; Noccioli, Bruno; Severi, Elisa; Carlini, Claudio; Vaccarella, Francesco; Camoglio, Francesco Saverio; Cesaro, Simone; Narciso, Alessandra; Riccipetitoni, Giovanna; Cecchetto, Giovanni; Inserra, Alessandro, Perioperative management of hypertensive neuroblastoma: A study from the Italian Group of Pediatric Surgical Oncologists (GICOP) «Journal of Pediatric Surgery» , vol. 52 , n. 10 , 2017 , pp. 1633-1636

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