Pubblicazioni

Autori:

Fezzi, Simone; Pighi, Michele; Del Sole, Paolo Alberto; Scarsini, Roberto; Mammone, Concetta; Zanforlin, Roberto; Ferrero, Valeria; Lunardi, Mattia; Tavella, Domenico; Pesarini, Gabriele; Ribichini, Flavio Luciano

Titolo:

Long-term intracoronary imaging and physiological measurements of bioresorbable scaffolds and untreated atherosclerotic plaques

Anno:

2024

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

INTERNATIONAL JOURNAL OF CARDIOLOGY

ISSN Rivista:

1874-1754

Intervallo pagine:

131341-131347

Parole chiave:

Bioresorbable vascular scaffold; Intravascular ultrasound; Optical coherence tomography; Quantitative flow ratio

Breve descrizione dei contenuti:

Background: Bioresorbable scaffolds (BRS) provide the prospect of restoring the anatomic and physiologic characteristics of the vascular wall. Objective: This study sought to examine the long-term outcomes of BRS-based coronary intervention in a young population with diffuse and severe coronary atherosclerotic disease (CAD) and to compare the long-term evolution of treated segments versus the natural progression of untreated non-flow limiting stenoses. Methods: Observational, single-center cohort study that prospectively included patients that underwent percutaneous coronary intervention with implantation of ABSORB BRS (Abbott Vascular). The clinical endpoint was the incidence of device-oriented composite endpoint (DoCE) up to 5 years follow-up. A subgroup of patients with baseline intracoronary imaging assessment of long lesions and/or multivessel disease underwent elective angiographic (70 patients, 129 lesions) and intracoronary imaging (55 patients, 102 lesions) follow-up. Paired intravascular ultrasound (IVUS) and quantitative flow reserve (QFR) were analyzed. Results: Between 2012 and 2017, 159 patients (mean age 54.0 ± 11.1) with native CAD were treated with BRS on 247 lesions. Patients were mainly at their first cardiac event, mostly acute coronary syndromes (86.5%). At the median follow-up time of 56 months [41-65], DoCE occurred in 15/159 (9.4%) patients, while non-target vessel-oriented composite endpoint occurred in 16 patients (10.4%). A significant atherosclerotic progression was detected on residual non-flow limiting plaques as per IVUS and QFR assessment, while no significant change was detected in the treated segment. Conclusions: Mild-to-moderate asymptomatic CAD progressed significantly at 5-year despite OMT. BRS-treated segments had a less aggressive progression at 5-year despite more severe and symptomatic CAD at baseline.

Id prodotto:

135204

Handle IRIS:

11562/1104508

ultima modifica:

30 ottobre 2024

Citazione bibliografica:

Fezzi, Simone; Pighi, Michele; Del Sole, Paolo Alberto; Scarsini, Roberto; Mammone, Concetta; Zanforlin, Roberto; Ferrero, Valeria; Lunardi, Mattia; Tavella, Domenico; Pesarini, Gabriele; Ribichini, Flavio Luciano, Long-term intracoronary imaging and physiological measurements of bioresorbable scaffolds and untreated atherosclerotic plaques «INTERNATIONAL JOURNAL OF CARDIOLOGY» , 2024 , pp. 131341-131347

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