Objectives. Recently, jawbone osteonecrosis has been reported as a potential adverse effect of bisphosphonates
administration. This paper considers and highlights histopathologic and radiologic features of this condition.
Study design. Eleven patients, owing to unresponsiveness to conservative treatment and uncontrollable pain, underwent
surgical resection of diseased jawbone after extensive hyperbaric oxygen therapy. A thorough clinical, laboratory, and
imaging study was performed. Surgical specimens underwent histopathologic and immunohistochemical evaluation.
Results. Computerized tomography (CT) scans showed increased bone density, periosteal reaction, and bone
sequestration in advanced stages. With magnetic resonance imaging (MRI), exposed areas showed a low signal in
T1- and T2-weighted and inversion recovery images, which suggests low water content and is histopathologically
correlated with paucity in cells and vessels (osteonecrotic pattern). Unexposed diseased bone was characterized by T1
hypointensity and T2 and IR hyperintensity, which suggests high water content and inflammation, associated with
hypercellularity, osteogenesis, and hypervascularity (osteomyelitic pattern).
Conclusions. Diseased bone extends beyond the limits of the bone exposed in the oral cavity. Histopathologic
examination correlated well with CT and MRI, which are the choice for the evaluation of bisphosphonate-associated
jawbone osteonecrosis.
Id prodotto:
55376
Handle IRIS:
11562/334261
depositato il:
29 marzo 2012
ultima modifica:
14 novembre 2022
Citazione bibliografica:
Bedogni, Alberto; Blandamura, S.; Lokmic, Z.; Palumbo, C.; Ragazzo, M.; Ferrari, Francesca; Tregnaghi, A.; Pietrogrande, F.; Procopio, O.; Saia, G.; Ferretti, M.; Bedogni, G.; Chiarini, L.; Ferronato, G.; Ninfo, V.; Lo Russo, L.; Lo Muzio, L.; Nocini, Pier Francesco,
Bisphosphonate-associated jawbone osteonecrosis: a correlation between imaging techniques and histopathology«ORAL SURGERY, ORAL MEDICINE, ORAL PATHOLOGY, ORAL RADIOLOGY AND ENDODONTICS»
, 2008
, pp. 358-364