Pubblicazioni

Autori:

De Bellis, Mario; Contro, Alberto; Bianco, Andrea; Gasparini, Clizia; Tripepi, Marzia; La Raja, Matilde; Alaimo, Laura; Conci, Simone; Campagnaro, Tommaso; Guglielmi, Alfredo; Mansueto, Giancarlo; Ruzzenente, Andrea

Titolo:

Portal vein stenting in recurrent or locally advanced peri-hilar cholangiocarcinoma

Anno:

2024

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

Elettronico

Referee:

No

Nome rivista:

European Journal of Surgical Oncology

ISSN Rivista:

0748-7983

N° Volume:

50

Numero o Fascicolo:

3

Intervallo pagine:

1-6

Parole chiave:

Locally advanced peri-hilar cholangiocarcinoma; Palliative treatment; Portal hypertension; Portal vein stenosis; Recurrent peri-hilar cholangiocarcinoma; Venous stent

Breve descrizione dei contenuti:

Background: Recurrent or locally advanced peri-hilar cholangiocarcinoma (PHCC) usually involves the portal vein (PV) leading to significant stenosis. With disease progression, clinical symptoms such as ascites, bleeding, and hepatic insufficiency are usually observed. Little is know about the benefit of PV stenting in relieving the symptoms associated to portal hypertension and allowing anticancer therapies. The aim of this study is to review our experience in PV stenting for PHCC patients. Methods: From 2014 to 2022, data from PHCC patients underwent PV stenting at Verona University Hospital, Italy, were reviewed. The indications were: gastrointestinal bleeding from esophagus-gastric varices, ascites not responsive to medical therapy, severe thrombocytopenia, liver insufficiency (hepatic jaundice, coagulopathy, and/or hyperammoniemia), or asymptomatic high-grade PV stenosis. Cavernous transformation and intrahepatic thrombosis in both sides of the liver were considered contraindication. Systematic anticoagulation therapy was not administered. Results: Technical success was achieved in all 16 (100 %) patients. The improvement of clinical symptoms were observed in 12 (75 %) patients. Anticancer therapy was administrated in 11 (69 %) patients. 2 (13 %) complications were observed: 1 biliary injury and 1 recurrent cholangitis that required a percutaneous trans-hepatic biliary drainage placement. Stent occlusion for tumor progression occurred in 1 patient and a re-stenting procedure was successfully performed. No case of thrombotic stent occlusion was observed during follow up. The 1-year stent patency was 86 % and the median patency period was 8 months (IQR, 4-12). Conclusion: PV stenting is a feasible and safe palliative treatment that improves clinical condition, allow anticancer therapies, and provide a better quality of life.

Id prodotto:

137651

Handle IRIS:

11562/1119067

ultima modifica:

26 giugno 2024

Citazione bibliografica:

De Bellis, Mario; Contro, Alberto; Bianco, Andrea; Gasparini, Clizia; Tripepi, Marzia; La Raja, Matilde; Alaimo, Laura; Conci, Simone; Campagnaro, Tommaso; Guglielmi, Alfredo; Mansueto, Giancarlo; Ruzzenente, Andrea, Portal vein stenting in recurrent or locally advanced peri-hilar cholangiocarcinoma «European Journal of Surgical Oncology» , vol. 50 , n. 3 , 2024 , pp. 1-6

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo