Pubblicazioni

In vivo investigation of hepatic iron overload in rats using T2 maps: quantification at high intensity field (4.7-T)  (2001)

Autori:
Fenzi A; Bortolazzi M; Marzola P;Colombari R
Titolo:
In vivo investigation of hepatic iron overload in rats using T2 maps: quantification at high intensity field (4.7-T)
Anno:
2001
Tipologia prodotto:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Lingua:
Inglese
Formato:
A Stampa
Referee:
Nome rivista:
Journal of Magnetic Resonance Imaging
ISSN Rivista:
1053-1807
N° Volume:
13
Intervallo pagine:
392-396
Parole chiave:
liver; iron; overload; MRI; T2 maps
Breve descrizione dei contenuti:
In vivo quantitation of hepatic Iron content is useful in diagnosis and staging of several iron related diseases. We used an experimental model of hepatic iron overload to determine the correlation between iron content and T2 relaxation time in rat liver. Experiments were carried out at 4.7T for high signal-to-noise ratio (SNR) using a spin-echo multiecho sequence with six echoes and minimum echo-time of 5.5 msec. The liver iron content was determined ex vivo by atomic absorption spectrophotometry (AAS). T2 maps were calculated in order to evaluate the space distribution of the iron content. We found good linear correlation between the in vivo liver transversal relaxation rate and the iron content within the range explored (106-4538 micrograms Fe/g liver wet wt.). T2 maps revealed that the decrease in T2 is not homogeneous through the liver parenchyma. This finding represents a physiological limitation to obtaining better correlation between T2 and iron content.
Id prodotto:
14183
Handle IRIS:
11562/304656
depositato il:
10 luglio 2012
ultima modifica:
16 agosto 2021
Citazione bibliografica:
Fenzi A; Bortolazzi M; Marzola P;Colombari R, In vivo investigation of hepatic iron overload in rats using T2 maps: quantification at high intensity field (4.7-T) «Journal of Magnetic Resonance Imaging» , vol. 132001pp. 392-396

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Titolo Dipartimento Responsabili
MRI evaluation of vivo liver concentration in human by means of T2-maps and signal to noise ratio. Dipartimento Scienze Chirurgiche Odontostomatologiche e Materno-Infantili Alberto Fenzi
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