Pubblicazioni

Autori:

Piro, Geny; Simionato, Francesca; Carbone, Carmine; Frizziero, Melissa; Malleo, Giuseppe; Zanini, SILVIA MARIA; Casolino, Raffaella; Santoro, Raffaela; Mina, Maria Mihaela; Zecchetto, Camilla; Merz, Valeria; Scarpa, Aldo; Bassi, Claudio; Tortora, Giampaolo; Melisi, Davide

Titolo:

A circulating TH2 cytokines profile predicts survival in patients with resectable pancreatic adenocarcinoma

Anno:

2017

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

ONCOIMMUNOLOGY

ISSN Rivista:

2162-4011

N° Volume:

6

Numero o Fascicolo:

9

Intervallo pagine:

1-7

Parole chiave:

circulating cytokine profile; IL4; pancreatic adenocarcinoma; prognostic biomarker; T; H; 2 cytokines;

Breve descrizione dei contenuti:

Surgery is the only potentially curative option for patients with pancreatic ductal adenocarcinoma (PDAC), but metastatic relapse remains common. We hypothesized that the expression levels of inflammatory cytokines could predict recurrence of PDAC, thus allowing to select patients who most likely could benefit from surgical resection. We prospectively collected plasma at diagnosis from two-hundred eighty-seven patients with pancreatic resectable neoplasms. The expression levels of 23 cytokines were measured in ninety patients with PDAC by using a multiplex analyte profiling assay. Levels higher than cutoff identified of the TH2 cytokines interleukin (IL)4, IL5, IL6, of macrophage inflammatory protein (MIP)1α, granulocyte-macrophage colony-stimulating factor (GM-CSF), and monocyte chemoattractant protein (MCP)1, and of IL17α, IFN-γ- induced protein (IP)10, and IL1β were significantly associated with a shorter median OS. In particular, levels of IL4 and IP10 higher than cutoff identified, and level of TH1 cytokines TNFα and INFγ, and of IL9 and IL1Rα lower than cutoff identified were significantly associated with a shorter DFS. In the multivariate analysis, high IP10 was confirmed as negatively associated with OS (HR = 3.097, P = 0.014) and IL4 and TNFα remain negatively (HR = 2.75, P = 0.002) and positively (HR = 0.224, P = 0.049) associated with DFS, respectively. Simultaneous expression of low IL4 and high TNFα identified patients with best prognosis (HR = 0.313, P<0.0001). In conclusion, we demonstrated that, among a series of cytokines, IL4 is the most significant independent prognostic factor for DFS in resectable PDAC patients, and it could be useful to select patients with high risk of early recurrence who may avoid an unnecessary resection.

Note:

The page range is based on the article PDF file

Id prodotto:

97803

Handle IRIS:

11562/963810

ultima modifica:

14 novembre 2022

Citazione bibliografica:

Piro, Geny; Simionato, Francesca; Carbone, Carmine; Frizziero, Melissa; Malleo, Giuseppe; Zanini, SILVIA MARIA; Casolino, Raffaella; Santoro, Raffaela; Mina, Maria Mihaela; Zecchetto, Camilla; Merz, Valeria; Scarpa, Aldo; Bassi, Claudio; Tortora, Giampaolo; Melisi, Davide, A circulating TH2 cytokines profile predicts survival in patients with resectable pancreatic adenocarcinoma «ONCOIMMUNOLOGY» , vol. 6 , n. 9 , 2017 , pp. 1-7

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