MRI evaluation of vivo liver concentration in human by means of T2-maps and signal to noise ratio.

Starting date
January 1, 2000
Duration (months)
36
Departments
Surgery, Dentistry, Paediatrics and Gynaecology
Managers or local contacts
Fenzi Alberto

In vivo quantitation of hepatic iron content is useful in diagnosis and staging of several iron related diseases. We used an experimental model of hepatic iron overload to determine the correlation between iron content and T2 relaxation time in rat liver. Experiments were carried out at 4.7T for high signal-to-noise ratio (SNR) using a spin-echo multiecho sequence with six echoes and minimum echo-time of 5.5 msec. The liver iron content was determined ex vivo by atomic absorption spectrophotometry (AAS). T2 maps were calculated in order to evaluate the space distribution of the iron content. We found good linear correlation between the in vivo liver transversal relaxation rate and the iron content within the range explored (106-4538 microg Fe/g liver wet wt.). T2 maps revealed that the decrease in T2 is not homogeneous through the liver parenchyma. This finding represents a physiological limitation to obtaining better correlation between T2 and iron content.

Sponsors:

Società Autostrade S.p.A.
Funds: assigned and managed by the department
Publications
Title Authors Year
In vivo investigation of hepatic iron overload in rats using T2 maps: quantification at high intensity field (4.7-T) Fenzi A; Bortolazzi M; Marzola P;Colombari R 2001

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