Publications

Authors:

Scarsini, Roberto; De Maria, Giovanni L; Di Gioia, Giuseppe; Kotronias, Rafail A; Aurigemma, Cristina; Zimbardo, Giuseppe; Burzotta, Francesco; Leone, Antonio M; Pesarini, Gabriele; Trani, Carlo; Crea, Filippo; Kharbanda, Rajesh K; De Bruyne, Bernard; Barbato, Emanuele; Banning, Adrian; Ribichini, Flavio

Title:

The Influence of Aortic Valve Obstruction on the Hyperemic Intracoronary Physiology: Difference Between Resting Pd/Pa and FFR in Aortic Stenosis

Year:

2019

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH

ISSN of journal:

1937-5395

N° Volume:

12

Number or Folder:

6

Page numbers:

539-550

Keyword:

Aortic stenosis; Coronary artery disease; Fractional flow reserve; Transcatheter aortic valve implantation

Short description of contents:

The reliability of fractional flow reserve (FFR) in aortic stenosis (AS) has been questioned because of the uncertain response to vasodilators. A retrospective multicenter cohort of 114 AS patients who underwent coronary physiology assessment was compared with 154 controls before and after propensity matching adjustment. The difference between resting distal coronary vs aortic pressure ratio (Pd/Pa) and FFR (ΔPd/Pa-FFR) was tested against the severity of AS. ΔPd/Pa-FFR was not influenced by the severity of AS in terms of aortic valve area (r = - 0.02, p = 0.83) and gradient (r = - 0.05, p = 0.64) or by the left ventricle hypertrophy (r = - 0.03, p = 0.88). Conversely, ΔPd/Pa-FFR was influenced by the presence of diabetes (r = - 0.24, p = 0.005), peripheral vascular disease (r = - 0.16, p = 0.047), and chronic kidney disease (r = - 0.19, p = 0.03). No significant difference was observed in the ΔPd/Pa-FFR between patients with AS and matched controls. Further studies are warranted to validate the FFR-guided revascularization in patients with AS.

Product ID:

111136

Handle IRIS:

11562/1004721

Last Modified:

November 8, 2022

Bibliographic citation:

Scarsini, Roberto; De Maria, Giovanni L; Di Gioia, Giuseppe; Kotronias, Rafail A; Aurigemma, Cristina; Zimbardo, Giuseppe; Burzotta, Francesco; Leone, Antonio M; Pesarini, Gabriele; Trani, Carlo; Crea, Filippo; Kharbanda, Rajesh K; De Bruyne, Bernard; Barbato, Emanuele; Banning, Adrian; Ribichini, Flavio, The Influence of Aortic Valve Obstruction on the Hyperemic Intracoronary Physiology: Difference Between Resting Pd/Pa and FFR in Aortic Stenosis «JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH» , vol. 12 , n. 6 , 2019 , pp. 539-550

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