Publications

Authors:

Bonafiglia, Elena; Gusson, Elena; Longo, Rosa; Ficial, Benjamim; Tisato, Maria Giulia; Rossignoli, Sara; Caltran, Giulia; Pedrotti, Emilio; Beghini, Renzo; Marchini, Giorgio

Title:

Early and late onset sepsis and retinopathy of prematurity in a cohort of preterm infants

Year:

2022

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

Sì

Name of journal:

SCIENTIFIC REPORTS

ISSN of journal:

2045-2322

N° Volume:

12

Number or Folder:

11675

Page numbers:

1-7

Keyword:

Eye diseases; Neonatal sepsis; Paediatric research; Retinal diseases; Retinopathy of prematurity

Short description of contents:

This study investigates the impact of antenatal and postnatal infection or inflammation on the onset and progression of Retinopathy of Prematurity (ROP). We retrospectively collected clinical and demographic data of preterm infants with birth weight ≤ 1500 g or gestational age < 30 weeks admitted to the neonatal intensive care unit of Verona from 2015 to 2019. Uni- and multivariable analysis was performed to evaluate the potential effect of selected variables on the occurrence of any stage ROP and its progression to severe ROP, defined as ROP requiring treatment. Two hundred and eighty neonates were enrolled and 60 of them developed ROP (21.4%). Oxygen need for 28 days and late-onset sepsis (LOS) increased the risk of any grade ROP after adjusting for birth weight and gestational age (OR 6.35, 95% CI 2.14-18.85 and OR 2.49, 95% CI 1.04-5.94, respectively). Days of mechanical ventilation and of non-invasive ventilation increased the risk of progression to severe ROP after adjusting for birth weight and gestational age (OR 1.08, CI 1.02-1.14 and OR 1.06, CI 1.01-1.11, respectively). Exposure to infection with production of inflammatory mediators may contribute to increase the risk of ROP occurrence in very preterm neonates.

Web page:

https://doi.org/10.1038/s41598-022-15804-4

Product ID:

127754

Handle IRIS:

11562/1070631

Last Modified:

February 23, 2023

Bibliographic citation:

Bonafiglia, Elena; Gusson, Elena; Longo, Rosa; Ficial, Benjamim; Tisato, Maria Giulia; Rossignoli, Sara; Caltran, Giulia; Pedrotti, Emilio; Beghini, Renzo; Marchini, Giorgio, Early and late onset sepsis and retinopathy of prematurity in a cohort of preterm infants «SCIENTIFIC REPORTS» , vol. 12 , n. 11675 , 2022 , pp. 1-7

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