Pubblicazioni

Extravalvular Cardiac Damage and Renal Function Following Transcatheter Aortic Valve Implantation for Severe Aortic Stenosis  (2021)

Autori:
Pighi, Michele; Fezzi, Simone; Pesarini, Gabriele; Venturi, Gabriele; Giovannini, Davide; Castaldi, Gianluca; Lunardi, Mattia; Ferrero, Valeria; Scarsini, Roberto; Ribichini, Flavio Luciano
Titolo:
Extravalvular Cardiac Damage and Renal Function Following Transcatheter Aortic Valve Implantation for Severe Aortic Stenosis
Anno:
2021
Tipologia prodotto:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Lingua:
Inglese
Referee:
No
Nome rivista:
CANADIAN JOURNAL OF CARDIOLOGY
ISSN Rivista:
0828-282X
N° Volume:
37
Numero o Fascicolo:
6
Intervallo pagine:
904-912
Parole chiave:
"cardiology"; "aortic stenosis"; "TAVI"; chronic kidney disease
Breve descrizione dei contenuti:
Background: In this study we sought to determine the differences in incidence of acute kidney injury (AKI) and acute kidney recovery (AKR) among patients undergoing transcatheter aortic valve implantation (TAVI), according to the degree of extravalvular cardiac damage (EVCD).Methods: From the Verona Valvular Heart Disease Registry, 674 symptomatic severe aortic stenosis (AS) patients were selected and retrospectively analysed. Using echocardiographic data, patients were classified based on the degree of EVCD.Results: After dichotomized analysis, patients in EVCD stage 3 or 4 reported a significantly higher rate of AKI (29.5% vs 11.2%; P < 0.001). Using a multivariate analysis model, higher EVCD stage, lower glomerular filtrate rate (GFR) at admission, and amount of contrast used were found to be independent predictors of AKI, whereas stage of cardiac damage and GFR were found to be independent predictors of AKR. For the overall population after multivariate analysis AKI was associated with a higher incidence of 12-month all-cause mortality (hazard ratio, 2.142; 95% confidence interval, 1.082-4.239; P = 0.029) with a significant impact in the advanced cardiac damage stages, but not in the early stages (P for interaction = 0.006). AKR did not reduce adverse clinical outcomes but was associated with improved renal function at 12 months.Conclusions: Increase in EVCD stage was associated with a higher rate of AKI after TAVI. AKI had a negative impact on long-term clinical outcomes but only in patients with advanced cardiac damage. AKR did not reduce adverse clinical outcomes but was associated with improved renal function at 12 months.
Id prodotto:
128089
Handle IRIS:
11562/1072269
ultima modifica:
23 febbraio 2023
Citazione bibliografica:
Pighi, Michele; Fezzi, Simone; Pesarini, Gabriele; Venturi, Gabriele; Giovannini, Davide; Castaldi, Gianluca; Lunardi, Mattia; Ferrero, Valeria; Scarsini, Roberto; Ribichini, Flavio Luciano, Extravalvular Cardiac Damage and Renal Function Following Transcatheter Aortic Valve Implantation for Severe Aortic Stenosis «CANADIAN JOURNAL OF CARDIOLOGY» , vol. 37 , n. 62021pp. 904-912

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo IRIS

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