Publications

Authors:

Pighi, Michele; Fezzi, Simone; Pesarini, Gabriele; Venturi, Gabriele; Giovannini, Davide; Castaldi, Gianluca; Lunardi, Mattia; Ferrero, Valeria; Scarsini, Roberto; Ribichini, Flavio Luciano

Title:

Extravalvular Cardiac Damage and Renal Function Following Transcatheter Aortic Valve Implantation for Severe Aortic Stenosis

Year:

2021

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

CANADIAN JOURNAL OF CARDIOLOGY

ISSN of journal:

0828-282X

N° Volume:

37

Number or Folder:

6

Page numbers:

904-912

Keyword:

"cardiology"; "aortic stenosis"; "TAVI"; chronic kidney disease

Short description of contents:

Background: In this study we sought to determine the differences in incidence of acute kidney injury (AKI) and acute kidney recovery (AKR) among patients undergoing transcatheter aortic valve implantation (TAVI), according to the degree of extravalvular cardiac damage (EVCD).Methods: From the Verona Valvular Heart Disease Registry, 674 symptomatic severe aortic stenosis (AS) patients were selected and retrospectively analysed. Using echocardiographic data, patients were classified based on the degree of EVCD.Results: After dichotomized analysis, patients in EVCD stage 3 or 4 reported a significantly higher rate of AKI (29.5% vs 11.2%; P < 0.001). Using a multivariate analysis model, higher EVCD stage, lower glomerular filtrate rate (GFR) at admission, and amount of contrast used were found to be independent predictors of AKI, whereas stage of cardiac damage and GFR were found to be independent predictors of AKR. For the overall population after multivariate analysis AKI was associated with a higher incidence of 12-month all-cause mortality (hazard ratio, 2.142; 95% confidence interval, 1.082-4.239; P = 0.029) with a significant impact in the advanced cardiac damage stages, but not in the early stages (P for interaction = 0.006). AKR did not reduce adverse clinical outcomes but was associated with improved renal function at 12 months.Conclusions: Increase in EVCD stage was associated with a higher rate of AKI after TAVI. AKI had a negative impact on long-term clinical outcomes but only in patients with advanced cardiac damage. AKR did not reduce adverse clinical outcomes but was associated with improved renal function at 12 months.

Product ID:

128089

Handle IRIS:

11562/1072269

Last Modified:

February 23, 2023

Bibliographic citation:

Pighi, Michele; Fezzi, Simone; Pesarini, Gabriele; Venturi, Gabriele; Giovannini, Davide; Castaldi, Gianluca; Lunardi, Mattia; Ferrero, Valeria; Scarsini, Roberto; Ribichini, Flavio Luciano, Extravalvular Cardiac Damage and Renal Function Following Transcatheter Aortic Valve Implantation for Severe Aortic Stenosis «CANADIAN JOURNAL OF CARDIOLOGY» , vol. 37 , n. 6 , 2021 , pp. 904-912

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