Publications

Authors:

Boscolo, Annalisa; Pasin, Laura; Sella, Nicolò; Pretto, Chiara; Tocco, Martina; Tamburini, Enrico; Rosi, Paolo; Polati, Enrico; Donadello, Katia; Gottin, Leonardo; Vianello, Andrea; Landoni, Giovanni; Navalesi, Paolo

Title:

Outcomes of COVID-19 patients intubated after failure of non-invasive ventilation: a multicenter observational study

Year:

2021

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

SCIENTIFIC REPORTS

ISSN of journal:

2045-2322

N° Volume:

11

Number or Folder:

1

Page numbers:

17730-17738

Keyword:

Aged; COVID-19; Female; Hospital Mortality; Humans; Intensive Care Units; Intubation, Intratracheal; Logistic Models; Male; Middle Aged; Multivariate Analysis; Noninvasive Ventilation; Outcome Assessment, Health Care; Respiratory Insufficiency; Risk Factors; SARS-CoV-2

Short description of contents:

The efficacy of non-invasive ventilation (NIV) in acute respiratory failure secondary to SARS-CoV-2 infection remains controversial. Current literature mainly examined efficacy, safety and potential predictors of NIV failure provided out of the intensive care unit (ICU). On the contrary, the outcomes of ICU patients, intubated after NIV failure, remain to be explored. The aims of the present study are: (1) investigating in-hospital mortality in coronavirus disease 2019 (COVID-19) ICU patients receiving endotracheal intubation after NIV failure and (2) assessing whether the length of NIV application affects patient survival. This observational multicenter study included all consecutive COVID-19 adult patients, admitted into the twenty-five ICUs of the COVID-19 VENETO ICU network (February-April 2020), who underwent endotracheal intubation after NIV failure. Among the 704 patients admitted to ICU during the study period, 280 (40%) presented the inclusion criteria and were enrolled. The median age was 69 [60-76] years; 219 patients (78%) were male. In-hospital mortality was 43%. Only the length of NIV application before ICU admission (OR 2.03 (95% CI 1.06-4.98), p = 0.03) and age (OR 1.18 (95% CI 1.04-1.33), p < 0.01) were identified as independent risk factors of in-hospital mortality; whilst the length of NIV after ICU admission did not affect patient outcome. In-hospital mortality of ICU patients intubated after NIV failure was 43%. Days on NIV before ICU admission and age were assessed to be potential risk factors of greater in-hospital mortality.

Product ID:

129733

Handle IRIS:

11562/1074749

Last Modified:

February 23, 2023

Bibliographic citation:

Boscolo, Annalisa; Pasin, Laura; Sella, Nicolò; Pretto, Chiara; Tocco, Martina; Tamburini, Enrico; Rosi, Paolo; Polati, Enrico; Donadello, Katia; Gottin, Leonardo; Vianello, Andrea; Landoni, Giovanni; Navalesi, Paolo, Outcomes of COVID-19 patients intubated after failure of non-invasive ventilation: a multicenter observational study «SCIENTIFIC REPORTS» , vol. 11 , n. 1 , 2021 , pp. 17730-17738

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