Publications

Authors:

Catarci, Marco; Ruffo, Giacomo; Viola, Massimo Giuseppe; Pirozzi, Felice; Delrio, Paolo; Borghi, Felice; Garulli, Gianluca; Baldazzi, Gianandrea; Marini, Pierluigi; Sica, Giuseppe; Gianluca, Guercioni; Paolo, Ciano; Benedetti, Michele; Simone, Cicconi; Irene, Marziali; Elisa, Bertocchi; Amedeo, Altamura; Francesco, Rubichi; Antonio, Sciuto; Ugo, Pace; Andrea Fares Bucci, ; Desirée, Cianflocca; Marco, Migliore; Basilio, Pirrera; Vincenzo, Alagna; Diletta, Cassini; Grazia Maria Attinà, ; Claudio, Arcudi; Bruno, Sensi; Roberto, Campagnacci; Angela, Maurizi; Massimo, Basti; Diletta, Frazzini; Valerio, Caracino; Pedrazzani, Corrado; Turri, Giulia; Mancini, Stefano; Andrea, Sagnotta; Marco, Scatizzi; Lorenzo, Pandolfini; Alessandro, Falsetto; Gian Luca Baiocchi, ; Sarah, Molfino; Mauro, Totis; Braga, Marco; Andrea, Liverani; Tatiana Di Cesare, ; Stefano, Scabini; Antonio, Martino; Raffaele De Luca, ; Michele, Simone; Alessandro, Carrara; Giuseppe, Tirone; Michele, Motter; Marco, Caricato; Gabriella Teresa Capolupo, ; Pietro, Amodio; Raffaele Macarone Palmieri, ; Maurizio, Pavanello; Carlo Di Marco, ; Andrea, Muratore; Patrizia, Marsanic; Alberto, Patriti; Valerio, Sisti; Andrea, Lucchi; Giacomo, Martorelli; Marco, Clementi; Stefano, Guadagni; Graziano, Longo; Federico, Tomassini; Simone, Santoni; Nereo, Vettoretto; Emanuele, Botteri; Andrea, Armellini; Giuseppe, Brisinda; Maria Michela Chiarello, ; Maria, Cariati; Stefano, Berti; Andrea, Gennai; Gabriele, Anania; Serena, Rubino; Walter, Siquini; Alessandro, Cardinali; DI COSMO, Mariantonietta; Zigiotto, Daniele; Lucio, Taglietti; Silvia, Ruggiero; DI LEO, Alberto; Jacopo, Andreuccetti; Paolo, Millo; Manuela, Grivon; Diana, Giannarelli

Title:

ERAS program adherence-institutionalization, major morbidity and anastomotic leakage after elective colorectal surgery: the iCral2 multicenter prospective study

Year:

2022

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

SURGICAL ENDOSCOPY

ISSN of journal:

0930-2794

N° Volume:

36

Number or Folder:

6

Page numbers:

3965-3984

Keyword:

Anastomotic leakage; Colorectal surgery; ERAS; Major morbidity; Anastomotic Leak; Humans; Institutionalization; Length of Stay; Male; Morbidity; Postoperative Complications; Prospective Studies; Colorectal Surgery; Enhanced Recovery After Surgery

Short description of contents:

Background Enhanced recovery after surgery (ERAS) programs influence morbidity rates and length of stay after colorectal surgery (CRS), and may also impact major complications and anastomotic leakage rates. A prospective multicenter observational study to investigate the interactions between ERAS program adherence and early outcomes after elective CRS was carried out. Methods Prospective enrolment of patients submitted to elective CRS with anastomosis in 18 months. Adherence to 21 items of ERAS program was measured upon explicit criteria in every case. After univariate analysis, independent predictors of primary endpoints [major morbidity (MM) and anastomotic leakage (AL) rates] were identified through logistic regression analyses including all significant variables, presenting odds ratios (OR). Results Institutional ERAS protocol was declared by 27 out of 38 (71.0%) participating centers. Median overall adherence to ERAS program items was 71.4%. Among 3830 patients included in the study, MM and AL rates were 4.7% and 4.2%, respectively. MM rates were independently influenced by intra- and/or postoperative blood transfusions (OR 7.79, 95% CI 5.46-11.10; p < 0.0001) and standard anesthesia protocol (OR 0.68, 95% CI 0.48-0.96; p = 0.028). AL rates were independently influenced by male gender (OR 1.48, 95% CI 1.06-2.07; p = 0.021), intra- and/or postoperative blood transfusions (OR 4.29, 95% CI 2.93-6.50; p < 0.0001) and non-standard resections (OR 1.49, 95% CI 1.01-2.22; p = 0.049). Conclusions This study disclosed wide room for improvement in compliance to several ERAS program items. It failed to detect any significant association between institutionalization and/or adherence rates to ERAS program with primary endpoints. These outcomes were independently influenced by gender, intra- and postoperative blood transfusions, non-standard resections, and standard anesthesia protocol.

Product ID:

130206

Handle IRIS:

11562/1078675

Last Modified:

February 23, 2023

Bibliographic citation:

Catarci, Marco; Ruffo, Giacomo; Viola, Massimo Giuseppe; Pirozzi, Felice; Delrio, Paolo; Borghi, Felice; Garulli, Gianluca; Baldazzi, Gianandrea; Marini, Pierluigi; Sica, Giuseppe; Gianluca, Guercioni; Paolo, Ciano; Benedetti, Michele; Simone, Cicconi; Irene, Marziali; Elisa, Bertocchi; Amedeo, Altamura; Francesco, Rubichi; Antonio, Sciuto; Ugo, Pace; Andrea Fares Bucci, ; Desirée, Cianflocca; Marco, Migliore; Basilio, Pirrera; Vincenzo, Alagna; Diletta, Cassini; Grazia Maria Attinà, ; Claudio, Arcudi; Bruno, Sensi; Roberto, Campagnacci; Angela, Maurizi; Massimo, Basti; Diletta, Frazzini; Valerio, Caracino; Pedrazzani, Corrado; Turri, Giulia; Mancini, Stefano; Andrea, Sagnotta; Marco, Scatizzi; Lorenzo, Pandolfini; Alessandro, Falsetto; Gian Luca Baiocchi, ; Sarah, Molfino; Mauro, Totis; Braga, Marco; Andrea, Liverani; Tatiana Di Cesare, ; Stefano, Scabini; Antonio, Martino; Raffaele De Luca, ; Michele, Simone; Alessandro, Carrara; Giuseppe, Tirone; Michele, Motter; Marco, Caricato; Gabriella Teresa Capolupo, ; Pietro, Amodio; Raffaele Macarone Palmieri, ; Maurizio, Pavanello; Carlo Di Marco, ; Andrea, Muratore; Patrizia, Marsanic; Alberto, Patriti; Valerio, Sisti; Andrea, Lucchi; Giacomo, Martorelli; Marco, Clementi; Stefano, Guadagni; Graziano, Longo; Federico, Tomassini; Simone, Santoni; Nereo, Vettoretto; Emanuele, Botteri; Andrea, Armellini; Giuseppe, Brisinda; Maria Michela Chiarello, ; Maria, Cariati; Stefano, Berti; Andrea, Gennai; Gabriele, Anania; Serena, Rubino; Walter, Siquini; Alessandro, Cardinali; DI COSMO, Mariantonietta; Zigiotto, Daniele; Lucio, Taglietti; Silvia, Ruggiero; DI LEO, Alberto; Jacopo, Andreuccetti; Paolo, Millo; Manuela, Grivon; Diana, Giannarelli, ERAS program adherence-institutionalization, major morbidity and anastomotic leakage after elective colorectal surgery: the iCral2 multicenter prospective study «SURGICAL ENDOSCOPY» , vol. 36 , n. 6 , 2022 , pp. 3965-3984

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo