Pubblicazioni

Autori:

Guerrini, Renzo; Specchio, Nicola; Aledo-Serrano, Ángel; Pringsheim, Milka; Darra, Francesca; Mayer, Thomas; Gil-Nagel, Antonio; Polster, Tilman; Zuberi, Sameer M; Lothe, Amélie; Gammaitoni, Arnold; Strzelczyk, Adam

Titolo:

An examination of the efficacy and safety of fenfluramine in adults, children, and adolescents with Dravet syndrome in a real-world practice setting: A report from the Fenfluramine European Early Access Program

Anno:

2022

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

Elettronico

Referee:

Sì

Nome rivista:

EPILEPSIA OPEN

ISSN Rivista:

2470-9239

Intervallo pagine:

1-10

Parole chiave:

Dravet syndrome; clinical practice; fenfluramine; refractory epilepsy; seizures

Breve descrizione dei contenuti:

Objective To examine the efficacy and safety of fenfluramine in patients with Dravet syndrome (DS) in three age groups: <6, 6-17, and >= 18 years old, treated in a real-world setting. Methods Patients with DS were treated with fenfluramine in the European Union Early Access Program (EAP). Following a 28-day baseline period to establish the pretreatment monthly convulsive seizure frequency (MCSF), fenfluramine was started at a dose chosen by the treating physician and gradually titrated based on efficacy and tolerability up to a maximum of 0.7 mg/kg/day. Seizure incidence was recorded in a written diary, and adverse events (AEs) were reported at each patient visit. Cardiovascular safety was assessed by transthoracic echocardiography before treatment started and at least every 6 months thereafter. Results A total of 149 patients have enrolled in the EAP and 63 were <6 years old, 62 were 6-17 years old, and 24 were >= 18 years old. After 3 months of treatment 62%, 53%, and 50% of patients demonstrated >= 75% reduction in MCSF in the <6, 6-17, and >= 18-year-old groups, respectively. This pattern of response was sustained through 12 months of treatment with 55%, 46%, and 80% of the <6, 6-17, and >= 18-year-old groups, respectively, experiencing a >= 75% reduction in MCSF. Most common AEs were loss of appetite (21%) and somnolence (16%). No valvular heart disease or pulmonary artery hypertension was observed. Significance The magnitude, consistency, and durability of the response to add-on fenfluramine is consistent across age groups in patients with Dravet syndrome.

Pagina Web:

https://onlinelibrary.wiley.com/doi/10.1002/epi4.12624

Id prodotto:

130274

Handle IRIS:

11562/1079691

ultima modifica:

23 gennaio 2025

Citazione bibliografica:

Guerrini, Renzo; Specchio, Nicola; Aledo-Serrano, Ángel; Pringsheim, Milka; Darra, Francesca; Mayer, Thomas; Gil-Nagel, Antonio; Polster, Tilman; Zuberi, Sameer M; Lothe, Amélie; Gammaitoni, Arnold; Strzelczyk, Adam, An examination of the efficacy and safety of fenfluramine in adults, children, and adolescents with Dravet syndrome in a real-world practice setting: A report from the Fenfluramine European Early Access Program «EPILEPSIA OPEN» , 2022 , pp. 1-10

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo