Publications

Authors:

Marchegiani, Giovanni; Barreto, Savio George; Bannone, Elisa; Sarr, Michael; Vollmer, Charles M; Connor, Saxon; Falconi, Massimo; Besselink, Marc G; Salvia, Roberto; Wolfgang, Christopher L; Zyromski, Nicholas J; Yeo, Charles J; Adham, Mustapha; Siriwardena, Ajith K; Takaori, Kyoichi; Hilal, Mohammad Abu; Loos, Martin; Probst, Pascal; Hackert, Thilo; Strobel, Oliver; Busch, Olivier R C; Lillemoe, Keith D; Miao, Yi; Halloran, Christopher M; Werner, Jens; Friess, Helmut; Izbicki, Jakob R; Bockhorn, Maximillian; Vashist, Yogesh K; Conlon, Kevin; Passas, Ioannis; Gianotti, Luca; Del Chiaro, Marco; Schulick, Richard D; Montorsi, Marco; Oláh, Attila; Fusai, Giuseppe Kito; Serrablo, Alejandro; Zerbi, Alessandro; Fingerhut, Abe; Andersson, Roland; Padbury, Robert; Dervenis, Christos; Neoptolemos, John P; Bassi, Claudio; Büchler, Markus W; Shrikhande, Shailesh V

Title:

Postpancreatectomy Acute Pancreatitis (PPAP): Definition and Grading From the International Study Group for Pancreatic Surgery (ISGPS)

Year:

2022

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

Annals of Surgery

ISSN of journal:

0003-4932

N° Volume:

275

Number or Folder:

4

Page numbers:

663-672

Keyword:

definition; International Study Group for Pancreatic Surgery; postpancreatectomy acute pancreatitis; postpancreatectomy acute pancreatitis

Short description of contents:

Objective: The ISGPS aimed to develop a universally accepted definition for PPAP for standardized reporting and outcome comparison. Background: : PPAP is an increasingly recognized complication after partial pancreatic resections, but its incidence and clinical impact, and even its existence are variable because an internationally accepted consensus definition and grading system are lacking. Methods: The ISGPS developed a consensus definition and grading of PPAP with its members after an evidence review and after a series of discussions and multiple revisions from April 2020 to May 2021. Results: We defined PPAP as an acute inflammatory condition of the pancreatic remnant beginning within the first 3 postoperative days after a partial pancreatic resection. The diagnosis requires (1) a sustained postoperative serum hyperamylasemia (POH) greater than the institutional upper limit of normal for at least the first 48 hours postoperatively, (2) associated with clinically relevant features, and (3) radiologic alterations consistent with PPAP. Three different PPAP grades were defined based on the clinical impact: (1) grade postoperative hyperamylasemia, biochemical changes only; (2) grade B, mild or moderate complications; and (3) grade C, severe life-threatening complications. Discussions: The present definition and grading scale of PPAP, based on biochemical, radiologic, and clinical criteria, are instrumental for a better understanding of PPAP and the spectrum of postoperative complications related to this emerging entity. The current terminology will serve as a reference point for standard assessment and lend itself to developing specific treatments and prevention strategies.

Product ID:

131928

Handle IRIS:

11562/1086004

Last Modified:

October 30, 2024

Bibliographic citation:

Marchegiani, Giovanni; Barreto, Savio George; Bannone, Elisa; Sarr, Michael; Vollmer, Charles M; Connor, Saxon; Falconi, Massimo; Besselink, Marc G; Salvia, Roberto; Wolfgang, Christopher L; Zyromski, Nicholas J; Yeo, Charles J; Adham, Mustapha; Siriwardena, Ajith K; Takaori, Kyoichi; Hilal, Mohammad Abu; Loos, Martin; Probst, Pascal; Hackert, Thilo; Strobel, Oliver; Busch, Olivier R C; Lillemoe, Keith D; Miao, Yi; Halloran, Christopher M; Werner, Jens; Friess, Helmut; Izbicki, Jakob R; Bockhorn, Maximillian; Vashist, Yogesh K; Conlon, Kevin; Passas, Ioannis; Gianotti, Luca; Del Chiaro, Marco; Schulick, Richard D; Montorsi, Marco; Oláh, Attila; Fusai, Giuseppe Kito; Serrablo, Alejandro; Zerbi, Alessandro; Fingerhut, Abe; Andersson, Roland; Padbury, Robert; Dervenis, Christos; Neoptolemos, John P; Bassi, Claudio; Büchler, Markus W; Shrikhande, Shailesh V, Postpancreatectomy Acute Pancreatitis (PPAP): Definition and Grading From the International Study Group for Pancreatic Surgery (ISGPS) «Annals of Surgery» , vol. 275 , n. 4 , 2022 , pp. 663-672

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