Publications

Authors:

Bennati, Lorenzo; Giambruno, Vincenzo; Renzi, Francesca; Di Nicola, Venanzio; Maffeis, Caterina; Puppini, Giovanni; Luciani, Giovanni Battista; Vergara, Christian

Title:

Turbulent blood dynamics in the left heart in the presence of mitral regurgitation: a computational study based on multi-series cine-MRI

Year:

2023

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

Sì

Name of journal:

BIOMECHANICS AND MODELING IN MECHANOBIOLOGY

ISSN of journal:

1617-7959

Page numbers:

1-18

Keyword:

Hemolysis; Blood washout; Mitral regurgitation; Computational fuid dynamics; Multi-series cine-MRI; Turbulence

Short description of contents:

In this work, we performed a computational image-based study of blood dynamics in the whole left heart, both in a healthy subject and in a patient with mitral valve regurgitation. We elaborated multi-series cine-MRI with the aim of reconstructing the geometry and the corresponding motion of left ventricle, left atrium, mitral and aortic valves, and aortic root of the subjects. This allowed us to prescribe such motion to computational blood dynamics simulations where, for the frst time, the whole left heart motion of the subject is considered, allowing us to obtain reliable subject-specifc information. The fnal aim is to investigate and compare between the subjects the occurrence of turbulence and the risk of hemolysis and of thrombi formation. In particular, we modeled blood with the Navier–Stokes equations in the arbitrary Lagrangian–Eulerian framework, with a large eddy simulation model to describe the transition to turbulence and a resistive method to manage the valve dynamics, and we used a fnite element discretization implemented in an in-house code for the numerical solution.

Product ID:

134557

Handle IRIS:

11562/1098386

Last Modified:

September 29, 2023

Bibliographic citation:

Bennati, Lorenzo; Giambruno, Vincenzo; Renzi, Francesca; Di Nicola, Venanzio; Maffeis, Caterina; Puppini, Giovanni; Luciani, Giovanni Battista; Vergara, Christian, Turbulent blood dynamics in the left heart in the presence of mitral regurgitation: a computational study based on multi-series cine-MRI «BIOMECHANICS AND MODELING IN MECHANOBIOLOGY» , 2023 , pp. 1-18

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