Publications

Authors:

Ministrini, Silvia; Bencivenga, Maria; Filippini, Federica; Mura, Gianni; Milandri, Carlo; Mazzei, Maria Antonietta; Bagnacci, Giulio; Berselli, Mattia; Monti, Manlio; Morgagni, Paolo; Solaini, Leonardo; Marrelli, Daniele; Piccioni, Stefania; De Pascale, Stefano; Graziosi, Luigina; Reddavid, Rossella; Rosa, Fausto; Belluco, Claudio; Tiberio, Guido

Title:

A pragmatic approach improves the clinical management of stage IV gastric cancer: Comparison between the Meta-Gastro results and the GIRCG's retrospective series

Year:

2024

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

European Journal of Surgical Oncology

ISSN of journal:

0748-7983

N° Volume:

50

Number or Folder:

1

Page numbers:

1-5

Keyword:

Curative surgery; Metastases; Multidisciplinary; Stage IV gastric cancer

Short description of contents:

Introduction: The Italian Research Group for Gastric Cancer developed a prospective database about stage IV gastric cancer, to evaluate how a pragmatic attitude impacts the management of these patients.Materials and methods: We prospectively collected data about metastatic gastric cancer patients thanks to cooperation between radiologists, oncologists and surgeons and we analyzed survival and prognostic factors, comparing the results to those obtained in our retrospective study.Results: Three-hundred and eighty-three patients were enrolled from 2018 to September 2022. We observed a higher percentage of laparoscopic exploration with peritoneal lavage in the prospective cohort. In the registry only 3.6 % of patients was submitted to surgery without associated chemotherapy, while in the retrospective population 44.3 % of patients were operated on without any chemotherapy. At univariate and multivariate analyses, the different metastatic sites did not show any survival differences among each other (OS 20.0 vs 16.10 vs 16.7 months for lymphnodal, peritoneal and hepatic metastases, respectively), while the number of metastatic sites and the type of treatment showed a statistical significance (OS 16,7 vs 13,0 vs 4,5 months for 1, 2 and 3 different metastatic sites respectively, p < 0.001; 24,2 vs 12,0 vs 2,5 months for surgery with/without chemo-therapy, chemotherapy alone and best supportive treatment respectively, p < 0.001).Conclusions: Our data highlight that the different metastatic sites did not show different survivals, but survival is worse in case of multiple localization. In patients where a curative resection can be achieved, acceptable survival rates are possible. A better diagnostic workup and a more accurate staging impact favorably upon survival.

Product ID:

137838

Handle IRIS:

11562/1119629

Last Modified:

September 22, 2024

Bibliographic citation:

Ministrini, Silvia; Bencivenga, Maria; Filippini, Federica; Mura, Gianni; Milandri, Carlo; Mazzei, Maria Antonietta; Bagnacci, Giulio; Berselli, Mattia; Monti, Manlio; Morgagni, Paolo; Solaini, Leonardo; Marrelli, Daniele; Piccioni, Stefania; De Pascale, Stefano; Graziosi, Luigina; Reddavid, Rossella; Rosa, Fausto; Belluco, Claudio; Tiberio, Guido, A pragmatic approach improves the clinical management of stage IV gastric cancer: Comparison between the Meta-Gastro results and the GIRCG's retrospective series «European Journal of Surgical Oncology» , vol. 50 , n. 1 , 2024 , pp. 1-5

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