Publications

Authors:

Molinari, Chiara; Solaini, Leonardo; Rebuzzi, Francesca; Tedaldi, Gianluca; Angeli, Davide; Petracci, Elisabetta; Prascevic, Dusan; Ewald, Jan; Rahm, Erhard; Canale, Matteo; Martinelli, Giovanni; Tomezzoli, Anna; Bencivenga, Maria; Ambrosio, Maria Raffaella; Marrelli, Daniele; Morgagni, Paolo; Ercolani, Giorgio; Ulivi, Paola; Saragoni, Luca

Title:

Genomic events stratifying prognosis of early gastric cancer

Year:

2024

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

Gastric Cancer

ISSN of journal:

1436-3291

N° Volume:

27

Number or Folder:

6

Page numbers:

1189-1200

Keyword:

ARID1A; LRP1B; EGC; Pen; Prognosis

Short description of contents:

Background The purpose of the study was to conduct a comprehensive genomic characterization of gene alterations, microsatellite instability (MSI), and tumor mutational burden (TMB) in submucosal-penetrating (Pen) early gastric cancers (EGCs) with varying prognoses. Methods Samples from EGC patients undergoing surgery and with 10-year follow-up data available were collected. Tissue genomic alterations were characterized using Trusight Oncology panel (TSO500). Pathway instability (PI) scores for a selection of 218 GC-related pathways were calculated both for the present case series and EGCs from the TCGA cohort. Results Higher age and tumor location in the upper-middle tract are significantly associated with an increased hazard of relapse or death from any cause (p = 0.006 and p = 0.032). Even if not reaching a statistical significance, Pen A tumors more frequently present higher TMB values, higher frequency of MSI-subtypes and an overall increase in PI scores, along with an enrichment in immune pathways. ARID1A gene was observed to be significantly more frequently mutated in Pen A tumors (p = 0.006), as well as in patients with high TMB (p = 0.027). Tumors harboring LRP1B alterations seem to have a higher hazard of relapse or death from any cause (p = 0.089), being mutated mainly in relapsed patients (p = 0.093). Conclusions We found that the most aggressive subtype Pen A is characterized by a higher frequency of ARID1A mutations and a higher genetic instability, while LRP1B alterations seem to be related to a lower disease-free survival. Further investigations are needed to provide a rationale for the use of these markers to stratify prognosis in EGC patients.

Product ID:

144860

Handle IRIS:

11562/1158389

Last Modified:

March 25, 2025

Bibliographic citation:

Molinari, Chiara; Solaini, Leonardo; Rebuzzi, Francesca; Tedaldi, Gianluca; Angeli, Davide; Petracci, Elisabetta; Prascevic, Dusan; Ewald, Jan; Rahm, Erhard; Canale, Matteo; Martinelli, Giovanni; Tomezzoli, Anna; Bencivenga, Maria; Ambrosio, Maria Raffaella; Marrelli, Daniele; Morgagni, Paolo; Ercolani, Giorgio; Ulivi, Paola; Saragoni, Luca, Genomic events stratifying prognosis of early gastric cancer «Gastric Cancer» , vol. 27 , n. 6 , 2024 , pp. 1189-1200

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