Publications

Authors:

Lazzari, Cecilia; Bosco, Mariachiara; Garzon, Simone; Simonetto, Chiara; Casarin, Jvan; Paolucci, Sonia; Cromi, Antonella; Ghezzi, Fabio; Uccella, Stefano

Title:

The impact of maternal age and body mass index on hypertensive disorders of pregnancy: Moving beyond the cut-off effect

Year:

2025

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

PREGNANCY HYPERTENSION

ISSN of journal:

2210-7789

N° Volume:

40

Page numbers:

1-10

Keyword:

Advanced maternal age; Continuous effect; Gestational hypertension; In vitro fertilization; Obesity; Preeclampsia

Short description of contents:

Objectives: Maternal age (MA) and body mass index (BMI) are known risk factors for hypertensive disorders of pregnancy (HDP). Different threshold values are used to calculate preeclampsia risk scores, but the appropriateness of a cut point model has not been extensively evaluated. This is because the effects of both MA and BMI occur continuously. We aimed to investigate the relationship between MA, BMI, and HDP, respecting the continuous nature of the two independent variables. Study design: We retrospectively selected all nulliparous women with singleton pregnancies who delivered after 22 gestational weeks from January 2005 to December 2019 (25,165 women). We used univariate and multivariable logistic regression analyses implementing linear, quadratic, cubic, and penalized splines functions to test, investigate, and describe the relationship between continuous BMI, continuous MA, and risk of HDP. Main outcome measures: MA, BMI, and infertility treatments are independently associated with the risk of developing all HDP in nulliparous women. The impacts of MA and BMI on the risk of developing HDP occur gradually, and penalized splines functions resulted in the best model to describe these associations with a different model for each HDP. No interaction factors were retained between MA, BMI, and infertility treatments. Conclusions: Given the relevance of HDP on maternal mortality, an accurate identification of women at increased risk of developing the disease is crucial. In an era where technology is rapidly advancing, new models for customized risk assessment of HDP, considering the continuous nature of MA and pregestational BMI, must be implemented.

Product ID:

145834

Handle IRIS:

11562/1162350

Last Modified:

May 17, 2025

Bibliographic citation:

Lazzari, Cecilia; Bosco, Mariachiara; Garzon, Simone; Simonetto, Chiara; Casarin, Jvan; Paolucci, Sonia; Cromi, Antonella; Ghezzi, Fabio; Uccella, Stefano, The impact of maternal age and body mass index on hypertensive disorders of pregnancy: Moving beyond the cut-off effect «PREGNANCY HYPERTENSION» , vol. 40 , 2025 , pp. 1-10

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