Publications

Authors:

Scribante, Andrea; Pardo, Alessia; Pascadopoli, Maurizio; Biagi, Federico; Schiepatti, Annalisa; Giammona, Valentina; Vecchio, Marco; Alquati, Christian; Modica, Gioia Giada; Casu, Cinzia; Butera, Andrea

Title:

Remineralizing Treatments for Dental Erosion and Sensitivity in Patients Suffering from Gastroesophageal Reflux Disease (GERD): Randomized Clinical Trial

Year:

2025

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

JOURNAL OF CLINICAL MEDICINE

ISSN of journal:

2077-0383

N° Volume:

14

Number or Folder:

10

Page numbers:

1-14

Keyword:

gastroesophageal reflux; hydroxyapatite; tooth erosion; tooth remineralization

Short description of contents:

Background: Gastroesophageal reflux disease (GERD) is a chronic condition that causes an abrupt decrease in salivary pH in the oral cavity, which can lead to demineralization, erosion, hypersensitivity, functional impairment, and possibly fracture of dental elements. The aim of this clinical study is to compare two types of treatment in patients with dental erosion diagnosed with gastroesophageal reflux. Methods: Thirty patients were enrolled in this randomized clinical trial. Each patient underwent clinical evaluation and esophageal pH measurement, in order to diagnose GERD. After an initial examination and assessment by an experienced dentist, the Trial group (15 patients) was assigned to home treatment with a zinc hydroxyapatite-based toothpaste and a hydroxyapatite-based paste, while the Control group (15 patients) was assigned to home treatment with zinc hydroxyapatite-based toothpaste only. The following indices were measured: Basic Erosive Wear Examination Index (BEWE); Schiff Air Index (SAI); Plaque Index (PI); and Bleeding Score (BS). Each index was assessed at T0 during the first visit, one month (T1), three months (T2), six months (T3), nine months (T4), and 12 months (T5). The Kolmogorov-Smirnov test was used to analyze the normality of the data, while Friedman's test followed by Dunn's post hoc test were used to compare the two groups (significance threshold: p < 0.05). Results: The results showed no statistically significant change in the BEWE and SAI indexes (p > 0.05). However, an improvement in dentin sensitivity and BS was observed. Plaque control also improved. Conclusions: The results of this study indicate that the additional hydroxyapatite paste did not significantly improve the outcomes of the study in respect to hydroxyapatite toothpaste alone. However, there was an improvement in the oral health of GERD patients using hydroxyapatite-based remineralizing treatment in terms of oral and periodontal indices calculated.

Product ID:

146476

Handle IRIS:

11562/1165567

Last Modified:

June 25, 2025

Bibliographic citation:

Scribante, Andrea; Pardo, Alessia; Pascadopoli, Maurizio; Biagi, Federico; Schiepatti, Annalisa; Giammona, Valentina; Vecchio, Marco; Alquati, Christian; Modica, Gioia Giada; Casu, Cinzia; Butera, Andrea, Remineralizing Treatments for Dental Erosion and Sensitivity in Patients Suffering from Gastroesophageal Reflux Disease (GERD): Randomized Clinical Trial «JOURNAL OF CLINICAL MEDICINE» , vol. 14 , n. 10 , 2025 , pp. 1-14

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo