Publications

Authors:

Fenzi, Alberto; Bortolazzi, Mirko; Marzola, Pasquina; Colombari, R.

Title:

In vivo investigation of hepatic iron overload in rats using T2 maps: quantification at high intensity field (4.7-T)

Year:

2001

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

Journal of Magnetic Resonance Imaging

ISSN of journal:

1053-1807

N° Volume:

13

Page numbers:

392-396

Keyword:

liver; iron; overload; MRI; T2 maps

Short description of contents:

In vivo quantitation of hepatic Iron content is useful in diagnosis and staging of several iron related diseases. We used an experimental model of hepatic iron overload to determine the correlation between iron content and T2 relaxation time in rat liver. Experiments were carried out at 4.7T for high signal-to-noise ratio (SNR) using a spin-echo multiecho sequence with six echoes and minimum echo-time of 5.5 msec. The liver iron content was determined ex vivo by atomic absorption spectrophotometry (AAS). T2 maps were calculated in order to evaluate the space distribution of the iron content. We found good linear correlation between the in vivo liver transversal relaxation rate and the iron content within the range explored (106-4538 micrograms Fe/g liver wet wt.). T2 maps revealed that the decrease in T2 is not homogeneous through the liver parenchyma. This finding represents a physiological limitation to obtaining better correlation between T2 and iron content.

Product ID:

14183

Handle IRIS:

11562/304656

Deposited On:

July 10, 2012

Last Modified:

November 26, 2022

Bibliographic citation:

Fenzi, Alberto; Bortolazzi, Mirko; Marzola, Pasquina; Colombari, R., In vivo investigation of hepatic iron overload in rats using T2 maps: quantification at high intensity field (4.7-T) «Journal of Magnetic Resonance Imaging» , vol. 13 , 2001 , pp. 392-396

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