Publications

Vascularized fibula flap reconstruction of the mandible in bisphosphonate-related osteonecrosis  (2009)

Authors:
Nocini, Pier Francesco; Saia, G.; Bettini, Giordana; Ragazzo, M.; Blandamura, S.; Chiarini, L.; Bedogni, Alberto
Title:
Vascularized fibula flap reconstruction of the mandible in bisphosphonate-related osteonecrosis
Year:
2009
Type of item:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Language:
Inglese
Referee:
Name of journal:
European Journal of Surgical Oncology
ISSN of journal:
0748-7983
Page numbers:
373-379
Keyword:
bisphosphonate; osteonecrosis; BRONJ; fibula flap; reconstruction; jaw
Short description of contents:
Aims: To point out the feasibility of microsurgical reconstruction of the mandible in patients with bisphosphonate-related osteonecrosis (BRONJ). Methods: Seven patients with extensive mandibular osteonecrosis underwent subtotal mandibulectomy and immediate reconstruction with a free fibula flap. They were six women and one man aged 49e72 years. The mean size of the bone and oral mucosa defects were 18.5 and 22.5 cm2 respectively. Results: The mean time of surgical intervention was 12 h. All flaps survived and the postoperative course was uneventful. Oral feeding was resumed 14 days after surgery in all cases. The donor legs healed without complications. The pathology report confirmed the diagnosis of BRONJ in all patients. Normal bone was detected at the resection margins in six out of seven patients. Patients were followed-up at intervals of 3 months. After a median follow-up time of 23 months, no clinical and radiographic evidence of recurrent BRONJ were detected in six patients. One patient with osteomyelitis at the resection margins had signs of recurrent BRONJ 6 months after surgery. The overall curative rate of the population was 86%. Conclusions: Despite the limited number of patients studied so far, our data show that mandible reconstruction with the fibula flap is feasible and does not influence the natural course of the primary disease in BRONJ-resected patients.
Product ID:
51449
Handle IRIS:
11562/334268
Deposited On:
March 29, 2012
Last Modified:
November 14, 2022
Bibliographic citation:
Nocini, Pier Francesco; Saia, G.; Bettini, Giordana; Ragazzo, M.; Blandamura, S.; Chiarini, L.; Bedogni, Alberto, Vascularized fibula flap reconstruction of the mandible in bisphosphonate-related osteonecrosis «European Journal of Surgical Oncology»2009pp. 373-379

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo IRIS

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