Publications

Authors:

Verlato, Giuseppe; Zanoni, Andrea; Tomezzoli, Anna; Minicozzi, Annamaria; Giacopuzzi, Simone; DI COSMO, Mariantonietta; Franceschetti, Ilaria; DE MANZONI, Giovanni

Title:

Response to induction therapy in oesophageal and cardia carcinoma using Mandard tumour regression grade or size of residual foci

Year:

2010

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

British Journal of Surgery

ISSN of journal:

0007-1323

N° Volume:

97

Number or Folder:

5

Page numbers:

719-725

Keyword:

induction therapy; oesophageal carcinoma; cardia carcinoma; chemoradiotherapy; Tumor Regression Grade; residual foci size

Short description of contents:

BACKGROUND:: Tumour regression grade (TRG) is used to evaluate responses to induction therapy in cancer of the oesophagus or cardia. This study aimed to determine whether inclusion of node category could improve the prognostic accuracy provided by TRG, and explore the prognostic value of an alternative classification based on size of residual foci and node category. METHODS:: Patients with oesophageal or cardia cancer treated with neoadjuvant chemoradiotherapy followed by resection were studied. Treatment-induced response at the primary site was evaluated by TRG and by a method whereby patients were classified as having no residual cancer, minimal residual disease (MRD) or as non-responders. RESULTS:: Between 2000 and 2007, 108 patients underwent resection. Disease-related survival decreased with increasing TRG in node-negative (N0) patients (P < 0.001), whereas in node-positive (N+) patients it was poor irrespective of TRG (P = 0.241). For N0 disease, 3-year survival in patients with MRD (58 (95 per cent confidence interval 26 to 80) per cent) was intermediate between that in patients with no residual cancer (85 (70 to 93) per cent) and non-responders (28 (4 to 59) per cent). Worst prognosis was for N+ disease (21 (9 to 36) per cent). CONCLUSION:: Node category should be considered when evaluating response to induction therapy in oesophageal or cardia cancer. A new classification based on size of residual foci and node category seems promising.

Web page:

http://www3.interscience.wiley.com/journal/123325466/abstract

Product ID:

87174

Handle IRIS:

11562/341198

Deposited On:

February 8, 2012

Last Modified:

November 15, 2022

Bibliographic citation:

Verlato, Giuseppe; Zanoni, Andrea; Tomezzoli, Anna; Minicozzi, Annamaria; Giacopuzzi, Simone; DI COSMO, Mariantonietta; Franceschetti, Ilaria; DE MANZONI, Giovanni, Response to induction therapy in oesophageal and cardia carcinoma using Mandard tumour regression grade or size of residual foci «British Journal of Surgery» , vol. 97 , n. 5 , 2010 , pp. 719-725

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