Publications

Long-term outcomes of surgical resection of the jaws in cancer patients with bisphosphonate-related osteonecrosis  (2011)

Authors:
Bedogni, A.; Saia, G.; Bettini, G.; Tronchet, A.; Totola, A.; Bedogni, G.; Ferronato, G.; Nocini, PF.; Blandamura, S.
Title:
Long-term outcomes of surgical resection of the jaws in cancer patients with bisphosphonate-related osteonecrosis
Year:
2011
Type of item:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Language:
Inglese
Referee:
No
Name of journal:
ORAL ONCOLOGY
ISSN of journal:
1368-8375
N° Volume:
47
Number or Folder:
5
Page numbers:
420-424
Keyword:
surgical resection, cancer, bisphosphonate, osteonecrosis
Short description of contents:
Surgical treatment of bisphosphonate-related osteonecrosis of the jaw (BRONJ) is controversial. Current recommendations contraindicate aggressive surgery because its results are unpredictable and may trigger disease progression. In this prospective study, we assessed the effectiveness of surgical resection of the jaws in cancer patients with BRONJ. Between June 2004 and July 2009, 30 cancer patients with refractory BRONJ underwent surgical resection of the jaws at our Units. They were followed-up weekly for the first month, at 3-month intervals up to 1 year, and at 6-month intervals up to 2 years. Panoramic radiographs and CT-scan were obtained at 3, 6, 12, 18 and 24 months. Primary outcomes were the 24-month recurrence rate of BRONJ and the 24-month mortality rate. Secondary outcomes were post-operative complications, duration of hospital stay after surgery, time to return to oral diet, and degree of oral pain.The 30 patients had a median age of 66 years and were mostly females (80%). Twenty-eight underwent a single resection and two had both jaws resected, for a total of 32 resected jaws. The cumulative recurrence rate of BRONJ in resected jaws 3.1% and 9.4% at 3 and 6 months, respectively. All the jaws with recurrent BRONJ had osteomyelitis at the margins of bone resection. The cumulative incidence of death was 3%, 12% and 16% at 12, 18 and 24 months.Surgical resection of BRONJ was highly effective, with few post-operative complications and were not associated with long-term mortality.
Product ID:
62107
Handle IRIS:
11562/363461
Deposited On:
October 28, 2013
Last Modified:
March 20, 2018
Bibliographic citation:
Bedogni, A.; Saia, G.; Bettini, G.; Tronchet, A.; Totola, A.; Bedogni, G.; Ferronato, G.; Nocini, PF.; Blandamura, S., Long-term outcomes of surgical resection of the jaws in cancer patients with bisphosphonate-related osteonecrosis «ORAL ONCOLOGY» , vol. 47 , n. 52011pp. 420-424

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