Publications

Authors:

Forni, Alberto; Luciani, GIOVANNI BATTISTA; Chiominto, Bartolomeo; Pizzuti, Manuela; Mazzucco, Alessandro; Faggian, Giuseppe

Title:

Results with expanded donor acceptance criteria in heart transplantation.

Year:

2011

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

Transplantation Proceedings

ISSN of journal:

0041-1345

N° Volume:

43

Number or Folder:

4

Page numbers:

953-959

Keyword:

transplantation, heart, LVAD, donor

Short description of contents:

Over the past years both donor and recipient profiles have changed in heart transplantation. Satisfactory clinical outcomes of marginal donors in candidates >60 years of age have led us to allocate suboptimal donors to younger recipients as well. Therefore, we retrospectively reviewed our experience.METHODS:Among 199 patients undergoing heart transplantation from January 2000 to February 2010, there were 83 (41%) aged 61-72 years. The other 116 (59%) ranged in age between 18 and 60 years. According to their clinical conditions as heart transplantation candidates, They were classified into 4 groups: younger recipients (n=116) of either optimal donors (n=72; group 1 [G1]) or marginal donors (n=44; group 2 [G2]) and older recipients (n=83) of either marginal grafts (n=70, group 3 [G3]) or optimal grafts (n=13; group 4 [G4]). The gender distribution, cause of end-stage heart failure, preoperative pulmonary hypertension incidence, pretransplantation clinical status, and mean follow-up were not significantly different among the 4 groups.RESULTS:Overall 30-day survival was 90 ± 1% and 10-year rate was 78 ± 9%. Among the groups, 30-day and 10-year actuarial survival rates were, respectively: 94 ± 4% and 87 ± 1% for G1; 86 ± 5% and 84 ± 7% for G2; 88 ± 4% and 71 ± 7% for G3 and were 100% and 82 ± 7% for G4 (P=.7). In comparison among the 4 groups, there was no significant difference regarding freedom from graft failure (P=.3), right ventricular failure (P=.3), acute rejection episodes (P = .2), chronic rejection (P=.2), neoplasia (P=.5), or chronic renal failure (P=.1). Older recipients of marginal donors [G3] had a 4% (n=3) prevalence of permanent pacemaker implant, versus G2: 3% (n=2) among (P=.1).CONCLUSION:Our results suggest that extended donor and recipient criteria do not compromise clinical outcomes after transplantation.

Product ID:

80473

Handle IRIS:

11562/662781

Deposited On:

April 9, 2014

Last Modified:

November 27, 2022

Bibliographic citation:

Forni, Alberto; Luciani, GIOVANNI BATTISTA; Chiominto, Bartolomeo; Pizzuti, Manuela; Mazzucco, Alessandro; Faggian, Giuseppe, Results with expanded donor acceptance criteria in heart transplantation. «Transplantation Proceedings» , vol. 43 , n. 4 , 2011 , pp. 953-959

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