Publications

Authors:

Fedele, Luigi; S., Bianchi; Raffaelli, Ricciarda; Zanconato, Giovanni

Title:

Comparison of transdermal estradiol and tibolone for the treatment of oophorectomized women with deep residual endometriosis

Year:

1999

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

Maturitas

ISSN of journal:

0378-5122

N° Volume:

32

Number or Folder:

3

Page numbers:

189-193

Keyword:

endometriosis; menopause; tibolone; estrogens

Short description of contents:

Tibolone may be a safe hormonal treatment for postmenopausal women with residual endometriosis. STUDY OBJECTIVE: To compare the effect of HRT with transdermal estradiol and that of treatment with tibolone in post-menopausal women with residual endometriosis. MATERIALS AND METHODS: 21 women with residual pelvic endometriosis after bilateral oophorectomy with or without hysterectomy were enrolled in the study and were randomized to HRT with transdermal estradiol 50 mg twice weekly (n = 10) associated with cyclic medroxyprogesterone acetate 10 mg daily in women who preserved uterus, and to treatment with tibolone 2.5 mg administered orally once a day (n = 11). The duration of both treatments was scheduled to last at least 12 months. Residual endometriosis was located in the bowel wall in four patients, in the rectovaginal septum in six and deeply in the retroperitoneal pelvic space in six. All women were symptomatic before oophorectomy. RESULTS: All the women were followed for 12 months. No patient suspended therapy because of side effects. Four patients of the estradiol group experienced moderate pelvic pain during treatment compared with only one patient in the tibolone group. One patient in the estradiol group reported severe dyspareunia. CONCLUSION: Although our series is very small, it seems that tibolone may be a safe hormonal treatment for post-menopausal women with residual endometriosis.

Product ID:

7443

Handle IRIS:

11562/7443

Deposited On:

May 16, 2008

Last Modified:

November 10, 2022

Bibliographic citation:

Fedele, Luigi; S., Bianchi; Raffaelli, Ricciarda; Zanconato, Giovanni, Comparison of transdermal estradiol and tibolone for the treatment of oophorectomized women with deep residual endometriosis «Maturitas» , vol. 32 , n. 3 , 1999 , pp. 189-193

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo