Publications

Authors:

Baldan, A.; Ferronato, Silvia; Olivato, Silvia; Malerba, Giovanni; Scuro, Alberto; Veraldi, GIAN FRANCO; Gelati, Matteo; Ferrari, Sergio; Mariotto, Sara; Pignatti, Pierfranco; Mazzucco, Sara; Gomez, Maria Macarena

Title:

Cyclooxygenase 2, toll-like receptor 4 and interleukin 1beta mRNA expression in atherosclerotic plaques of type 2 diabetic patients.

Year:

2014

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

Inflammation Research

ISSN of journal:

1023-3830

N° Volume:

63

Number or Folder:

10

Page numbers:

851-858

Keyword:

cyclooxygenase 2, inflammation, type 2 diabetes, atherosclerosis

Short description of contents:

Objectives and design: Inflammation has a prominent role in the development of atherosclerosis. Type 2 diabetes could contribute to atherosclerosis development by promoting inflammation. This status might accelerate changes in intrinsic vascular wall cells and favor plaque formation. Cyclooxygenase 2 (COX-2) is highly expressed in atherosclerotic plaques. COX-2 gene expression is promoted through activation of toll-like receptor 4 (TLR4) and pro-inflammatory cytokine interleukin 1β (IL1-β). Aim of this study is to investigate whether expression profiles of pro-inflammatory genes such as COX-2, TLR4 and IL1-β in atherosclerotic plaques are altered in type 2 diabetes (T2D).Methods: Total RNA was isolated from plaques of atherosclerotic patients and expression of COX-2, TLR4, IL1-β analyzed using real-time PCR. Histological analysis was performed on sections of the plaque to establish the degree of instability.Results: Statistically significant differences in mRNA expression of COX-2 and IL1-β were found in plaques of T2D compared with non-T2D patients. A multi-variable linear regression model suggests that COX-2 mRNA expression is affected by T2D pathology and IL1-β mRNA expression in atherosclerotic plaques.Conclusions: Our results support the hypothesis that T2D pathology contributes in vivo to increase the inflammatory process associated with the atherosclerotic plaque formation, as shown by an increment of COX-2 and IL1-β mRNA expression.

Web page:

http://dx.doi.org/10.1007/s00011-014-0759-8

Product ID:

83423

Handle IRIS:

11562/774166

Deposited On:

November 4, 2014

Last Modified:

November 15, 2022

Bibliographic citation:

Baldan, A.; Ferronato, Silvia; Olivato, Silvia; Malerba, Giovanni; Scuro, Alberto; Veraldi, GIAN FRANCO; Gelati, Matteo; Ferrari, Sergio; Mariotto, Sara; Pignatti, Pierfranco; Mazzucco, Sara; Gomez, Maria Macarena, Cyclooxygenase 2, toll-like receptor 4 and interleukin 1beta mRNA expression in atherosclerotic plaques of type 2 diabetic patients. «Inflammation Research» , vol. 63 , n. 10 , 2014 , pp. 851-858

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo