Publications

Authors:

Mauro, Margherita; Camoglio, Francesco Saverio; Piccoli, Pierluigi; De Bortoli, Massimiliano; Balter, Rita; Pegoraro, Anna; Cesaro, Simone

Title:

The Use of Splenectomy to Manage Platelet Transfusion Refractoriness due to Anti-Human Leukocyte Antibodies in Allogeneic Stem Cell Transplantation

Year:

2016

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

PEDIATRIC REPORTS

ISSN of journal:

2036-749X

N° Volume:

8

Number or Folder:

1

Page numbers:

1-3

Keyword:

allogeneic stem cell transplantation; alloimmunized patients; anti-HLA; splenectomy; transfusion refractoriness

Short description of contents:

In patients undergoing hematopoietic stem cell transplantation (HSCT), refractoriness to platelet transfusion has been associated with graft failure, delayed engraftment, early mortality and decreased overall survival. Therapeutic strategies include plasma exchange, immunoglobulins, rituximab, and splenectomy. We describe here three patients with refractoriness to platelet transfusion due to anti-human leukocyte antibodies who were splenectomized before HSCT (two cases) and after HSCT (one case) due to the lack of efficacy of other therapies. Splenectomy was uneventful. All three patients achieved a full donor engraftment. We suggest that splenectomy is feasible and effective in HSCT patients to reduce the risk of graft failure or delayed engraftment.

Product ID:

93802

Handle IRIS:

11562/944770

Last Modified:

November 14, 2022

Bibliographic citation:

Mauro, Margherita; Camoglio, Francesco Saverio; Piccoli, Pierluigi; De Bortoli, Massimiliano; Balter, Rita; Pegoraro, Anna; Cesaro, Simone, The Use of Splenectomy to Manage Platelet Transfusion Refractoriness due to Anti-Human Leukocyte Antibodies in Allogeneic Stem Cell Transplantation «PEDIATRIC REPORTS» , vol. 8 , n. 1 , 2016 , pp. 1-3

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