Publications

Authors:

Gusella, M; Giacopuzzi, Simone; Bertolaso, Loris; Zanoni, Andrea; Pezzolo, Elena; Modena, Y; Menon, D; Paganin, P; Weindelmayer, Jacopo; Crepaldi, G; DE MANZONI, Giovanni; Pasini, Felice

Title:

Genetic prediction of long-term survival after neoadjuvant chemoradiation in locally advanced esophageal cancer

Year:

2017

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

PHARMACOGENOMICS JOURNAL

ISSN of journal:

1470-269X

N° Volume:

17

Number or Folder:

3

Page numbers:

252-257

Keyword:

esophageal cancer, Genetic prediction of response

Short description of contents:

Candidate genes involved in DNA repair, 5-fluorouracil metabolism and drug detoxification were genotyped in 124 patients receiving neoadjuvant chemoradiation treatment for locally advanced esophageal cancer and their predictive role for long-term relapse-free survival (RFS) and cancer-specific survival (CSS) were evaluated. A panel including MTHFR 677TT, MDR1 2677GT, GSTP1 114CC, XPC 499CC and XPC 939AC+CC, defined as high-risk genotypes, discriminated subgroups with significantly different outcomes. When the panel was combined with histology, patients split into two subsets with 5-year RFS and CSS rates of 65% vs 27% (hazard ratio (HR) 3.0, P<0.0001) and 69% vs 31% (HR 2.9, P<0.0001), respectively. Combining the 5-single-nucleotide polymorphism (5-SNP) panel with pathological response defined two major informative risk classes with 5-year PFS and CSS rates of 79.4% vs 17.7% (HR 6.71, P<0.0001) and 79.3% vs 26.3% (HR 6.25, P<0.0001), respectively. This classification achieved a sensitivity of 79%, a specificity of 85.4% and an accuracy of 81.8%.The Pharmacogenomics Journal advance online publication, 1 March 2016; doi:10.1038/tpj.2016.9.

Product ID:

95132

Handle IRIS:

11562/955225

Last Modified:

November 15, 2022

Bibliographic citation:

Gusella, M; Giacopuzzi, Simone; Bertolaso, Loris; Zanoni, Andrea; Pezzolo, Elena; Modena, Y; Menon, D; Paganin, P; Weindelmayer, Jacopo; Crepaldi, G; DE MANZONI, Giovanni; Pasini, Felice, Genetic prediction of long-term survival after neoadjuvant chemoradiation in locally advanced esophageal cancer «PHARMACOGENOMICS JOURNAL» , vol. 17 , n. 3 , 2017 , pp. 252-257

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