Publications

Authors:

Kinnunen, Eeva Maija; Zanobini, Marco; Onorati, Francesco; Brascia, Debora; Mariscalco, Giovanni; Franzese, Ilaria; Ruggieri, Vito G; Bounader, Karl; Perrotti, Andrea; Musumeci, Francesco; Santarpino, Giuseppe; Maselli, Daniele; Nardella, Saverio; Gulbins, Helmut; Gherli, Riccardo; Rubino, Antonino S; Mignosa, Carmelo; De Feo, Marisa; Gatti, Giuseppe; Santini, Francesco; Salsano, Antonio; Dalén, Magnus; Saccocci, Matteo; Reichart, Daniel; Faggian, Giuseppe; Gherli, Tiziano; Nicolini, Francesco; Biancari, Fausto

Title:

The impact of minor blood transfusion on the outcome after coronary artery bypass grafting

Year:

2017

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

JOURNAL OF CRITICAL CARE

ISSN of journal:

0883-9441

N° Volume:

40

Page numbers:

207-212

Keyword:

Bleeding, Cardiac surgery, Coronary artery bypass grafting, Red blood cell, Transfusion

Short description of contents:

Purpose: To investigate the impact of minor perioperative bleeding requiring transfusion of 1-2 red blood cell (RBC) units on the outcome after coronary artery bypass grafting (CABG). Methods: Sixteen cardiac surgical centers contributed to the prospective European CABG registry (E-CABG). 1014 patients receiving 1-2 RBC units during or after isolated CABG were compared to 2264 patients not receiving RBCs. Results: In 827 propensity score matched pairs, transfusion of 1-2 RBC units did not affect the risk of in-hospital/30-day death (p = 0.523) or stroke (p = 0.804). However, RBC transfusion was associated with an increased risk of acute kidney injury (p = 0.008), sternal wound infection (p = 0.001), postoperative use of antibiotics (p = 0.001), prolonged use of inotropes (p < 0.0001), use of intra-aortic balloon pump (p = 0.012), length of intensive care unit stay (p < 0.0001) and length of in-hospital stay (p < 0.0001). Matched paired analysis excluding pre- and postoperative critical hemodynamic conditions showed that RBC transfusion was associated with an increased risk of major complications except in-hospital/30-day death. Conclusion: Minor perioperative bleeding and subsequent transfusion of 1-2 RBC units did not affect the risk of early death, but increased the risk of other major adverse events. Minimizing perioperative bleeding and prevention of even low-volume RBC transfusion may improve the outcome after CABG.

Product ID:

98167

Handle IRIS:

11562/964984

Last Modified:

November 15, 2022

Bibliographic citation:

Kinnunen, Eeva Maija; Zanobini, Marco; Onorati, Francesco; Brascia, Debora; Mariscalco, Giovanni; Franzese, Ilaria; Ruggieri, Vito G; Bounader, Karl; Perrotti, Andrea; Musumeci, Francesco; Santarpino, Giuseppe; Maselli, Daniele; Nardella, Saverio; Gulbins, Helmut; Gherli, Riccardo; Rubino, Antonino S; Mignosa, Carmelo; De Feo, Marisa; Gatti, Giuseppe; Santini, Francesco; Salsano, Antonio; Dalén, Magnus; Saccocci, Matteo; Reichart, Daniel; Faggian, Giuseppe; Gherli, Tiziano; Nicolini, Francesco; Biancari, Fausto, The impact of minor blood transfusion on the outcome after coronary artery bypass grafting «JOURNAL OF CRITICAL CARE» , vol. 40 , 2017 , pp. 207-212

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