Publications

Authors:

Bonafini, Sara; Tagetti, Angela; Gaudino, Rossella; Cavarzere, Paolo; Montagnana, Martina; Danese, Elisa; Benati, Marco; Ramaroli, DIEGO ALBERTO; Raimondi, Sara; Giontella, Alice; Mantovani, Anna; Donato, Angela; Dalbeni, Andrea; Minuz, Pietro; Antoniazzi, Franco; Maffeis, Claudio; Fava, Cristiano

Title:

Individual fatty acids in erythrocyte membranes are associated with several features of the metabolic syndrome in obese children

Year:

2019

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

EUROPEAN JOURNAL OF NUTRITION

ISSN of journal:

1436-6215

N° Volume:

58

Number or Folder:

2

Page numbers:

731-742

Keyword:

Arachidonic acid; Children; Metabolic syndrome; Non-alcoholic fatty liver disease; Omega-6 fatty acids; Palmitic acid; Saturated fatty acids

Short description of contents:

Purpose: Obesity leads to the clustering of cardiovascular (CV) risk factors and the metabolic syndrome (MetS) also in children and is often accompanied by non-alcoholic fatty liver disease. Quality of dietary fat, beyond the quantity, can influence CV risk profile and, in particular, omega-3 fatty acids (FA) have been proposed as beneficial in this setting. The aim of the study was to evaluate the associations of individual CV risk factors, characterizing the MetS, with erythrocyte membrane FA, markers of average intake, in a group of 70 overweight/obese children. Methods: We conducted an observational study. Erythrocyte membrane FA were measured by gas chromatography. Spearman correlation coefficients (r S ) were calculated to evaluate associations between FA and features of the MetS. Results: Mean content of Omega-3 FA was low (Omega-3 Index = 4.7 ± 0.8%). Not omega-3 FA but some omega-6 FA, especially arachidonic acid (AA), were inversely associated with several features of the MetS: AA resulted inversely correlated with waist circumference (r S = − 0.352), triglycerides (r S = − 0.379), fasting insulin (r S = − 0.337) and 24-h SBP (r S = − 0.313). Total amount of saturated FA (SFA) and specifically palmitic acid, correlated positively with waist circumference (r S = 0.354), triglycerides (r S = 0.400) and fasting insulin (r S = 0.287). Fatty Liver Index (FLI), a predictive score of steatosis based on GGT, triglycerides and anthropometric indexes, was positively correlated to palmitic acid (r S = 0.515) and inversely to AA (r S = − 0.472). Conclusions: Our data suggest that omega-6 FA, and especially AA, could be protective toward CV risk factors featuring the MetS and also to indexes of hepatic steatosis in obese children, whereas SFA seems to exert opposite effects.

Web page:

https://doi.org/10.1007/s00394-018-1677-2

Product ID:

102029

Handle IRIS:

11562/977460

Last Modified:

November 15, 2022

Bibliographic citation:

Bonafini, Sara; Tagetti, Angela; Gaudino, Rossella; Cavarzere, Paolo; Montagnana, Martina; Danese, Elisa; Benati, Marco; Ramaroli, DIEGO ALBERTO; Raimondi, Sara; Giontella, Alice; Mantovani, Anna; Donato, Angela; Dalbeni, Andrea; Minuz, Pietro; Antoniazzi, Franco; Maffeis, Claudio; Fava, Cristiano, Individual fatty acids in erythrocyte membranes are associated with several features of the metabolic syndrome in obese children «EUROPEAN JOURNAL OF NUTRITION» , vol. 58 , n. 2 , 2019 , pp. 731-742

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