Publications

Authors:

Mauro, Margherita; Saggiorato, Graziella; Sartori, Maria Teresa; Gallo, Giuseppe; De Bortoli, Massimiliano; Bonetti, Elisa; Zaccaron, Ada; Vitale, Virginia; Balter, Rita; Chinello, Matteo; Cesaro, Simone

Title:

Venoocclusive disease due to chemotherapy for pediatric acute lymphoblastic leukemia is associated with increased levels of plasminogen-activator inhibitor-1

Year:

2018

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

PEDIATRIC BLOOD & CANCER

ISSN of journal:

1545-5009

N° Volume:

65

Number or Folder:

6

Page numbers:

26963-26966

Keyword:

acute lymphoblastic leukemia; plasminogen-activator inhibitor-1 (PAI-1); sinusoidal obstructive syndrome; venoocclusive disease; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Female; Hepatic Veno-Occlusive Disease; Humans; Male; Plasminogen Activator Inhibitor 1; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis

Short description of contents:

We describe three cases of sinusoidal obstruction syndrome/venoocclusive disease (SOS) in pediatric patients with acute lymphoblastic leukemia (ALL). All three episodes occurred during or just after the induction or reinduction phase of treatment based on prednisone/dexamethasone, vincristine, daunorubicin, and pegylated-l-asparaginase. SOS episodes were categorized as mild/moderate and resolved in 7, 10, and 16 days using supportive measures or defibrotide therapy. In all three episodes, the clinical diagnosis of SOS was associated with a significant increase in plasminogen-activator inhibitor-1 (PAI-1) that reduced with patient clinical improvement. PAI-1 warrants study as a diagnostic marker for SOS in ALL.

Product ID:

109274

Handle IRIS:

11562/997256

Last Modified:

November 15, 2022

Bibliographic citation:

Mauro, Margherita; Saggiorato, Graziella; Sartori, Maria Teresa; Gallo, Giuseppe; De Bortoli, Massimiliano; Bonetti, Elisa; Zaccaron, Ada; Vitale, Virginia; Balter, Rita; Chinello, Matteo; Cesaro, Simone, Venoocclusive disease due to chemotherapy for pediatric acute lymphoblastic leukemia is associated with increased levels of plasminogen-activator inhibitor-1 «PEDIATRIC BLOOD & CANCER» , vol. 65 , n. 6 , 2018 , pp. 26963-26966

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